"OPB Politics Now" is a weekly podcast that takes a deep dive into the hottest political topics in Oregon and the Northwest. Every Friday, OPB’s political reporters and special guests offer in-depth analysis, discussion and insight into candidates, events and issues.
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Content provided by Khalil Diab. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Khalil Diab or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
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Reprogramming Immunity: Unlocking CAR-NK Cells with Dr. Hind Rafei
Manage episode 491527921 series 3609908
Content provided by Khalil Diab. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Khalil Diab or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
In this episode, Dr. Hind Rafei dives into the cutting-edge world of CAR-NK cell therapy and its potential to revolutionize cancer treatment. Unlike their T-cell counterparts, CAR-NK cells promise enhanced safety and innate tumor-killing ability. But what if their power could be dialed up even further?
Dr. Rafei discusses her team's groundbreaking discovery of CREM, a transcriptional regulator that shapes CAR-NK function and limits its full therapeutic potential. We explore how modulating CREM—particularly by deleting or suppressing it—can reprogram these cells to become more effective, resilient cancer fighters.
We unpack the science behind the PKA–CREB pathway, CREM-driven epigenetic changes, and how these findings might lead to next-generation immunotherapies and even cancer vaccines. Finally, Dr. Rafei offers insights on clinical translation and the path ahead for CREM-tuned therapies.
Whether you’re a researcher, clinician, or patient advocate, this episode sheds light on one of the most promising frontiers in cellular immunotherapy.
#CARNKCells
#CellTherapy
#CancerImmunotherapy
#GeneEditing
#Epigenetics
#TranscriptionFactors
#CREMgene
#CancerBiology
#ImmunoOncology
#NextGenTherapies
#CancerInnovation
#PodcastEpisode
#SciencePodcast
#MedicalPodcast
#CancerResearch
#Immunotherapy
132 episodes
Share
Manage episode 491527921 series 3609908
Content provided by Khalil Diab. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Khalil Diab or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
In this episode, Dr. Hind Rafei dives into the cutting-edge world of CAR-NK cell therapy and its potential to revolutionize cancer treatment. Unlike their T-cell counterparts, CAR-NK cells promise enhanced safety and innate tumor-killing ability. But what if their power could be dialed up even further?
Dr. Rafei discusses her team's groundbreaking discovery of CREM, a transcriptional regulator that shapes CAR-NK function and limits its full therapeutic potential. We explore how modulating CREM—particularly by deleting or suppressing it—can reprogram these cells to become more effective, resilient cancer fighters.
We unpack the science behind the PKA–CREB pathway, CREM-driven epigenetic changes, and how these findings might lead to next-generation immunotherapies and even cancer vaccines. Finally, Dr. Rafei offers insights on clinical translation and the path ahead for CREM-tuned therapies.
Whether you’re a researcher, clinician, or patient advocate, this episode sheds light on one of the most promising frontiers in cellular immunotherapy.
#CARNKCells
#CellTherapy
#CancerImmunotherapy
#GeneEditing
#Epigenetics
#TranscriptionFactors
#CREMgene
#CancerBiology
#ImmunoOncology
#NextGenTherapies
#CancerInnovation
#PodcastEpisode
#SciencePodcast
#MedicalPodcast
#CancerResearch
#Immunotherapy
132 episodes
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Similar to The Lebanese Physicians' Podcast
"OPB Politics Now" is a weekly podcast that takes a deep dive into the hottest political topics in Oregon and the Northwest. Every Friday, OPB’s political reporters and special guests offer in-depth analysis, discussion and insight into candidates, events and issues.
…
continue reading
Tough decisions rattle us all to the core. But for our guests on One Decision— the choices they are up against can also shape history. No pressure! They take us through all of their doubts, emotions and—sometimes unexpected--consequences. A fresh take on foreign policy. Hear the former head of Mi6, Sir Richard Dearlove alongside international journalists as they analyse, interview, and discuss.
…
continue reading
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continue reading
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…
continue reading
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…
continue reading
The Seen and the Unseen, hosted by Amit Varma, features longform conversations that aim to give deep insights into the subjects being discussed. Timeless and bingeworthy.
…
continue reading
America’s premier Sunday morning public affairs program. For nearly 70 years, Face the Nation has sought to help audiences understand how current events affect their lives. Today, that mission remains the same. Hear moderator Margaret Brennan’s illuminating and informative interviews with elected officials, policy experts and foreign leaders. Face the Nation airs Sundays at 10:30 AM, ET on the CBS Television Network and at 12 PM, ET on the CBS News Streaming Network. Face the Nation is also ...
…
continue reading
Guardian columnist John Harris, political editor Pippa Crerar, and political correspondent Kiran Stacey analyse the week's politics news
…
continue reading
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Player FM - Podcast App
Go offline with the Player FM app!
Go offline with the Player FM app!
