Antibiotic CRI’s: Better Than Bolus? With Prof Steve Epstein. Bonus - Live At IVECCS

The Vet Vault: Fall In Love With Veterinary Science

If you caught my conversation with Prof. Steve Epstein from IVECCS 2024, you already know this:

When it comes to septic patients, timing of antibiotics is everything. Ok, maybe not EVERYTHING, because in our follow-up discussion 1 year later at IVECCS 25, Prof Steve explored an idea that might just shift your ICU protocols: duration of administration matters.

That’s the idea behind the concept is prolonged infusion - giving time-dependent antibiotics over extended periods for more sustained bacterial kill time. (Spoiler alert: it works. BUT...with a few caveats.)

Jump in to this one for a straight-forward data backed action you can take with your critical patients that will save more lives.

Topics We Unpacked:

• Time-dependent vs. concentration-dependent antibiotics
• Prolonged infusion vs. continuous rate infusion (CRI)
• Human evidence: findings from the BLING III trial
• Applicability of human data to veterinary patients
• Dosing challenges and pharmacokinetics in septic animals
• Practical recommendations for veterinary ICU settings
  

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