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Untangling PANDAS & PANS: Conversations about Infection-Associated, Immune-Mediated Neuropsychiatric Disorders
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S2 E12: The Neuropathology of PANDAS/PANS: Dr. Brent Harris Talks about the POND Brain Bank
Manage episode 474414481 series 3567249
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This podcast episode features an interview with Dr. Brent Harris, the Director of Neuropathology at Georgetown University where he wears many hats, including overseeing the Georgetown Brain Bank. In 2020, he accepted the brain of Alex Manfull who had died from complications due to PANDAS and, eventually, with the help of The Alex Manfull Fund, established the POND Brain Bank for brains and brain tissue from individuals who had been diagnosed with "PANDAS/PANS and Other Neuroimmune Disorders." Dr. Harris talks about neuropathology, the role of brain banks in facilitating research on brain disorders, and findings from the first published clinicopathologic case report of a young adult diagnosed with PANDAS. He explains how gliosis, a marker of brain injury found in that case, can occur after a neurological insult and how it might be reversible in some cases; it is not a condition expected to be observed in healthy 26-year-old individuals. Additionally, he emphasizes the importance of more research and better recognition of conditions like PANDAS/PANS in the medical community to improve diagnosis and treatment. The episode touches on the evolving understanding of these diseases and the critical role of clinical research and education.
The POND Brain Bank at Georgetown University
https://neurology.georgetown.edu/patientcare/pond-brain-bank/
Clinicopathologic Characteristics of PANDAS in a Young Adult: A Case Report
https://karger.com/dne/article/45/6/335/862829/Clinicopathologic-Characteristics-of-PANDAS-in-a
Disclaimer: The views and opinions expressed in this program are those of the speakers and do not necessarily reflect the views or positions of any entities they represent.
Credits: Music by Kingsley Durant from his "Convertible" album
To learn more about PANDAS and PANS and The Alex Manfull Fund, visit our website: TheAlexManfullFund.org
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Chapters
1. S2 E12: The Neuropathology of PANDAS/PANS: Dr. Brent Harris Talks about the POND Brain Bank (00:00:00)
2. Introduction to PANDAS and PANS (00:00:07)
3. Meet Dr. Brent Harris, Neuropathologist (00:04:06)
4. Understanding Neuropathology's Role in Medicine (00:08:01)
5. Creating the POND Brain Bank (00:19:19)
6. The Importance of Postmortem Brain Analysis (00:31:24)
7. First PANDAS/PANS Brain Study Findings (00:43:29)
8. Future Research and Nomenclature Challenges (00:59:43)
9. Closing Thoughts and Brain Donation Information (01:15:34)
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