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💪 Powerful Cholesterol Control: Obicetrapib in the Spotlight 🌟
Manage episode 481177842 series 2740117
Content provided by MasterMedFacts LLC and RR Baliga MD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MasterMedFacts LLC and RR Baliga MD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
🚀 Obicetrapib: A Breakthrough in LDL Lowering!
📉 Reduced LDL by 29.9% in high-risk patients (p
471 episodes
Manage episode 481177842 series 2740117
Content provided by MasterMedFacts LLC and RR Baliga MD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MasterMedFacts LLC and RR Baliga MD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
🚀 Obicetrapib: A Breakthrough in LDL Lowering!
📉 Reduced LDL by 29.9% in high-risk patients (p
471 episodes
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1 Dr RR Baliga's Philosophical Discourses: Nagarjuna (India, c. 150 CE) – Founder of Madhyamaka School 3:52
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Nāgārjuna (c. 150 – c. 250 CE) was an Indian Buddhist monk and philosopher, regarded as the founder of the Madhyamaka (Middle Way) school of Mahāyāna Buddhism. His most famous work, Mūlamadhyamakakārikā (Root Verses on the Middle Way), presents the concept of śūnyatā (emptiness) and the two truths doctrine, emphasizing dependent origination and rejecting inherent existence. Nāgārjuna’s philosophy has profoundly influenced Mahāyāna thought and continues to shape Buddhist studies and practice today.…

1 🫀Low-Voltage Areas in AF, The SUPPRESS-AF Showdown! 3:36
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📢 New RCT in Nature Medicine 🎯 Can zapping low-voltage areas (LVAs) reduce AF recurrence after PVI? 🔬 SUPPRESS-AF Trial 👥 342 pts with persistent AF 📉 1-yr AF/AT-free: 61% (PVI+LVA) vs 50% (PVI) ❌ Not statistically significant 🧠 Subgroup benefit in high-risk pts #EPeeps #AFib #CardioTwitter 🫀

1 Muscles, Memory, and Molecules 🧠💪🧬: Predicting Strength Decline with Alzheimer’s Biomarkers 3:36
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🧠💪 Can blood biomarkers of Alzheimer’s predict who’ll lose muscle strength with age? In a 12-year study, higher p-tau, NfL & GFAP levels forecasted faster decline in grip & leg power — even before dementia onset. 🧬🪑✊ #Aging #Alzheimers #Sarcopenia #Biomarkers #Longevity

1 🚶♂️ The Great Sit-Down: A Decade of Sitting Habits 2:52
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📉 New JAMA study tracks U.S. #SedentaryBehavior from 2013–2023: 🪑 Sitting time fell from 7.1 to 5.9 hrs/day pre-COVID 🦠 But plateaued post-pandemic at 6.0 hrs/day 🚶♀️ Progress stalled—time to get moving again! #PublicHealth #NHANES #PhysicalActivity 🏃♂️📊🛋️

1 🐒 No Drama, Just Mama: Wild Chimps Show Secure Attachment 5:36
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🐒 New study finds no disorganized attachment in wild chimpanzees! 🧠 Only secure & avoidant types observed—just like humans, but without the trauma. 🌿 Evolution favors calm, connected bonds. 📍Taï National Park, Côte d’Ivoire 🔗 Nature knows best. #PrimateScience #AttachmentTheory #Chimpanzees

1 “💡Tiny Pulse, Big Impact: Dissolving Pacemakers Powered by Light” 2:53
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💡World’s tiniest pacemaker—smaller than a grain of rice! 🫀Leadless, wireless & bioresorbable 🔦 Powered by NIR light 🧬 Perfect for post-op pacing & TAVR 🌱 No wires, no scars, no removal! #MedTech #Cardiology #Bioengineering #Innovation @Nature

1 “Cut the Cysteine, Burn the Fat, Jolt the Genome 🔪🔥🧬” 3:25
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Cutting cysteine = 🔥 30% weight loss in 7 days! 🧬 Triggers stress pathways (ISR/OSR) ❌ CoA & glutathione drop 🔥 Browning fat, futile cycling, energy drain 💡 Reversible & promising for obesity research! #Metabolism #Obesity #AminoAcids #Science 🧪⚖️🧠

1 Battle of the Heart Valves: 🔍: Myval Matches, ACURATE Misses ❌, SAPIEN Stands Strong 💪 5:50
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🚨 TAVI Trials Update! 🆚 COMPARE-TAVI 1: 🇮🇳Myval = 💪SAPIEN 3 in safety & efficacy 🆚 ACURATE IDE: ACURATE neo2 ❌not non-inferior to 💥SAPIEN/EVOLUT 📊 Valve wars intensify! #TAVI #HeartValve #Cardiology 🫀

1 “Not All Heat Is Equal: Science Behind the Chili Burn 🌡️🧠🌶️” 3:07
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🌶️ Not all chili heat is created equal! Scientists found hidden compounds—like capsianoside I & roseoside—that cool the burn without changing flavor 🔬❄️ Your next spicy dish might be hot… but not hurt. #FlavorScience #Capsaicin #TRPV1 #FoodTech 🍽️🧠🔥

1 🚨 Tiny Twists, Big Clues: Vortices Reveal Chemotherapy’s Toll 4:05
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📊 New study shows Topological Flow Data Analysis (TFDA) 🌀 detects early cardiac dysfunction in childhood cancer survivors— before LVEF or strain drop! 🔍 A game-changer in cardio-onc surveillance. #CardioOncology #TFDA #EchoRevolution
📉 Mucus plugs matter! In COPD, persistent or new plugs accelerate FEV₁ decline 🫁💨 🖥️ CT imaging tracks their impact 🚬 Smoking worsens the hit 👉 Clear the plugs, preserve the lungs! #COPD #LungHealth #NEJM #FEV1 #Pulmonology

1 💥 Old Drugs, New Power: Amiloride vs Spironolactone in Resistant Hypertension 4:24
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🩺 New hope for #ResistantHypertension! A 12-week RCT 🇰🇷 shows 💊 amiloride is noninferior to spironolactone in lowering SBP 📉 Fewer side effects, similar BP drop! But spironolactone may still reign 👑 for organ protection 🫀🧠 🧪 #Hypertension #Cardiology #JAMA2025

1 🧪 Precision for One, Promise for Many: CRISPR Meets the Clinic--A New Era in Rare Disease Therapy 6:43
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🧬✨ A baby with deadly CPS1 deficiency (which results in elevated ammonia levels) gets a custom-made gene edit—delivered by lipid nanoparticles—in just 6 months! 🚀 Ammonia levels down, no hospitalizations, and hope up. N-of-1? More like Future-of-Many. 💡👶🔬 #GeneTherapy #PrecisionMedicine #RareDisease…

1 🔥 Smoldering Systems: Staging Systemic Metabolic Disorder Before It Ignites 3:40
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🚨 New framework alert! Systemic Metabolic Disorder (SMD) gets a clinical staging makeover 🧬 From reversible risks 🌱 to systemic damage 🔥—this EAS consensus guides timely, targeted care 🎯 #MetabolicHealth #Cardiology #PrecisionMedicine #SMD 🩺📊

1 Dr RR Baliga's Philosophical Discourses: Pyrrho (Greece, c. 360–270 BCE) – Founder of Pyrrhonism 4:16
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Pyrrho of Elis (c. 360–270 BCE) was an ancient Greek philosopher and founder of Pyrrhonism, a school of philosophical skepticism. He advocated for epoché (suspension of judgment) as a path to ataraxia (peace of mind). Influenced by his travels to India with Alexander the Great, Pyrrho believed that nothing could be definitively known and that by refraining from beliefs, one could achieve tranquility. His teachings laid the foundation for later skeptical thought in philosophy and medicine.…
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