Welcome to the MedEvidence! podcast, hosted by Dr. Michael Koren. MedEvidence, where we help you navigate the real truth behind medical research with both a clinical and research perspective. In this podcast, we will discuss with physicians with extensive experience in patient care and research. How do you know that something works? In medicine, we conduct clinical trials to see if things work! Now, let's get to the Truth Behind the Data. Contact us at www.MedEvidence.com
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🕗Ever wondered why there's so much advertising around AFib?
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6:31Send us a text Dr. Michael Koren joins Kevin Geddings to discuss why atrial fibrillation (AFib) receives so much attention in advertising compared to other services hospitals provide. The cardiologist explains the financial incentives for hospitals and device manufacturers behind these marketing campaigns, contrasting them with clinical research, w…
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🎙Inside the Inflammatory Cascade: Understanding Psoriasis
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35:44Send us a text Dr. Michael Bernhardt, a dermatologist and clinical researcher, joins Dr. Erich Schramm to discuss the revolutionary advancements in psoriasis treatment over the past two decades. The doctors discuss how psoriasis is an inflammatory disease more than an autoimmune disease. They discuss what inflammation is, the inflammation pathway i…
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🎙Migraines: Navigating The War Zone Ep. 297
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57:03Send us a text Doctor Carolyn Tran joins Neurologist Steven Toenjes to discuss migraines. Migraine is a complex brain disease affecting one in five women and one in ten men, with treatments ranging from traditional medications to cutting-edge therapies targeting specific pathways in the brain. The doctors talk about the causes - or lack thereof, th…
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🕗 Beyond mRNA: Novavax Gets FDA Approval Ep. 296
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8:44Send us a text The FDA has granted full approval to Novavax's COVID-19 vaccine, providing an alternative to mRNA vaccines that works through a different mechanism using proteins and adjuvants. Despite being four years into the pandemic, COVID-19 remains a significant health concern, causing approximately 1 in 200 deaths in the US in 2025. • Novavax…
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🕗 Oral COVID Vaccines: A New Frontier Ep. 295
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10:52Send us a text Dr. Michael Koren shares exciting news about the revival of an oral COVID vaccine study previously halted by government spending cuts. The non-mRNA vaccine trial represents an important alternative approach that apparently received priority status even under strict budget reviews. • Oral COVID vaccine study in Jacksonville now active…
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🎙From PSA to Personalized Prostate Care, Part 3 Ep. 294
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14:52Send us a text Urologist and president of the Duval County Medical Society Dr. Ali Kasraeian joins Dr. Michael Koren to update us on recent advances in Urology. In Part 3 of this series, Dr. Koren and Dr. Kasraeian dive deep into the latest advancements in prostate cancer detection and treatment options. They explore the evolution from basic PSA sc…
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🕗Breaking Medical Barriers in Saudi Arabia Ep. 293
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7:19Send us a text Dr. Michael Koren shares insights from his recent speaking tour across Saudi Arabia where he delivered 14 lectures in 6 days to sophisticated healthcare providers eager for American medical research. His observations reveal surprising aspects of Saudi healthcare including English as the professional language, universal insurance cove…
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🎙From PSA to Personalized Prostate Care, Part 2 Ep. 292
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18:18Send us a text Urologist and president of the Duval County Medical Society Dr. Ali Kasraeian joins Dr. Michael Koren to update us on recent advances in Urology. In Part 2 of this series, Dr. Koren and Dr. Kasraeian explore into the controversial history of PSA testing. Dr. Kasraeian explains how this simple blood test revolutionized prostate cancer…
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🎙From PSA to Personalized Prostate Care, Part 1 Ep. 291
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16:00Send us a text Urologist and president of the Duval County Medical Society Dr. Ali Kasraeian joins Dr. Michael Koren to update us on recent advances in Urology. In Part 1 of this series, Dr. Kasraeian talks about his journey, from growing up in a medical family to becoming a urologist and healthcare advocate with a passion for innovative approaches…
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🎙Why Being in a Clinical Trial May Reduce Your Medical Risk Ep. 290
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16:30Send us a text Dr. Michael Koren sits down with Dr. Murali Ramaswamy to explore the concept of Research as a Care Option. They compare this with the misconception of research as a treatment option to reveal how clinical trials provide structured environments that often lead to better health outcomes regardless of the specific intervention. They deb…
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🕗How Tariffs May Impact Your Medical Costs Ep. 289
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9:01Send us a text Dr. Michael Koren joins Kevin Geddings to discuss how tariffs could significantly impact pharmaceutical prices. They talk about how barriers to import may affect both prescription and especially over-the-counter medication prices. They move onto the difficulty of starting new drug manufacturing in the US and how clinical trials may p…
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🎙COPD Causes, Symptoms, and Modern Treatment Approaches Ep. 288
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45:21Send us a text On this episode, recorded in front of a live audience, Cardiologist Dr. Michael Koren is joined by pulmonologist Dr. Mitchell Rothstein to discuss Chronic Obstructive Pulmonary Disease (COPD). COPD is obstruction of the lungs, making it hard to breathe and represents a significant health challenge . It affects millions of Americans a…
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🕗 John Lennon's Last Concert Highlights Research Ethics Ep 287
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6:02Send us a text Dr. Michael Koren Join Kevin Geddings to reflect on the evolution of medical research ethics from the troubling practices at Willowbrook Hospital in the 1970s to today's patient-centered approach. He connects this progression to John Lennon and Yoko Ono's final major concert, which raised awareness about conditions at the hospital wh…
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🕗Cholesterol Report from the American College of Cardiology Ep. 286
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9:19Send us a text Dr. Michael Koren shares insights from his presentation at the American College of Cardiology meeting in Chicago about a groundbreaking oral PCSK9 inhibitor that could lower cholesterol by 80% when combined with a statin. The development represents a significant advancement in treatment options for the 20% of patients who don't respo…
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🎙Artificial Intelligence in Psychiatric Care Ep. 285
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22:22Send us a text Psychiatrist Dr. Rachna Saralka joins Cardiologist Dr. Michael Koren to explore the emerging field of artificial intelligence in psychology. They discuss the promise and shortfalls of using AI in this field, and the need for hard data and validated results through clinical trials. They get into empathy, the placebo effect, and potent…
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🕗The Final Four of Pharmaceuticals: Basketball Championships Can Teach Us About Drug Development Ep. 284
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5:57Send us a text On this Monday Morning Minute, Dr. Michael Koren draws parallels between the NCAA Final Four basketball tournament and the clinical research process. He explains that in medicine, researchers start with literally 10,000 potential molecules, which get whittled down to only three or four medications to be tested in big, phase III clini…
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🎙Ghana to Florida; Emergency Room to Home Ep. 283
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34:52Send us a text Judith Abbey, DNP, shares her journey from medical student in Ghana to healthcare entrepreneur in Florida, where she founded On the Go Drip, a mobile IV therapy service delivering treatments directly to patients' homes. Dr. Michael Koren asks her about her history and business, and the two of them dive into some of the controversy su…
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🕗 Single-Pill Solution Could Reduce Cholesterol by 80% Ep. 282
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9:02Send us a text Cardiologist Dr. Michael Koren joins Kevin Geddings to discuss progress in the world of cholesterol management. Dr. Koren explains the importance of getting cholesterol - especially LDL cholesterol - under control and the potential benefits to heart attack and stroke risk. They discuss some of the problems with current therapies; the…
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Send us a text On This week’s episode, Dr. Michael Koren Interviews local media entrepreneur Randall Thomas, host of PB and Jax. They discuss how “The Internet is a Weird Place.” They examine the algorithms, platforms, and biases that make up our experience on the internet. Mr. Thomas explains how the algorithms determine what gains traction and th…
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🎙When the Teleprompter Gets Blurry: Ken Amaro's Wake-Up Call Ep. 280
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50:38Send us a text Ken Amaro, a former broadcaster with 42 years of experience and current Jacksonville City Councilman for District 1, joins Eric Ross, RN. Ken shares his decade-long journey with Type 2 diabetes from diagnosis through management and lifestyle adaptations, dropping motivational nuggets and tips he's learned along the way. The two discu…
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🕗 A "Healthy Look" at Clinical Trial Participation Ep. 279
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7:14Send us a text On this week's Monday Morning Minute, Dr. Michael Koren joins Kevin Geddings to answer the question "can I participate in clinical trials even if I'm not sick?" They discuss how having "healthy participants" is critical for some clinical trials. They look at a current study that examines how the body processes oral statin medications…
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🎙 Community Health Initiatives with Jacksonville's Chief Health Officer Ep. 278
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40:29Send us a text In this episode, Dr. Michael Koren is joined by Dr. Sunil Joshi, the Chief Health Officer of the city of Jacksonville, Florida. Dr. Joshi runs through five health initiatives to lower the premature death rate in the city and county. The doctors discuss health inequalities, the social and economic factors that contribute to negative h…
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🕗 Gastric Bypass Results Without the Surgery? Ep. 277
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6:56Send us a text This week Dr. Koren Joins Kevin Geddings for the Monday Morning Minute to talk about a clinical research procedure to resurface a part of the digestive system that contributes to obesity and diabetes. This program is currently being studied in northeast Florida. Dr. Koren explains how the device works, it's expected results, and how …
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🎙Beyond Cholesterol: Inflammation And Heart Disease Ep. 276
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38:12Send us a text Dr. Trevor Greene joins Dr. Michael Koren to discuss the effects of inflammation on the cardiovascular system. The two cardiologists talk about biomarkers that have increasing importance: including liporprotein(a) and hsCRP. The doctors finish up with actionable lifestyle changes everyone can implement. Koren's Key Takeaways: Inflamm…
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🕗 Medical Devices: Beyond Pills and Vaccines Ep. 275
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6:21Send us a text Most pills are taken daily, and many vaccines protect for around a year, but could medical device products last even longer? In this episode of the Monday Morning Minute, Dr. Michael Koren joins Kevin Geddings and explains what medical devices are and how they can make long-term differences for patients. The two discuss device treatm…
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🎙 Journavx (Suzetrigine): The Future of Pain Medication Ep. 274
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21:43Send us a text Anesthesiologist Dr. Todd Bertoch speaks with Dr. Michael Koren in this exciting episode about the a new pain medication, Journavx (suzetrigine), which was just approved by the FDA in January, 2025. The doctors discuss this breakthrough pain management medication, its safety profile, side effects, and how it compares to NSAIDs, aceta…
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🕗 Alcohol Warning Labels: Helpful or Harmful? Ep. 273
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10:20Send us a text Kevin Geddings talks with Cardiologist Dr. Michael Koren about the health risks and benefits of alcohol, which continue to be significant topics of discussion in health circles. This episode delves into a late Biden-era proposal for alcohol warning labels amid growing concerns about cancer risks associated with consumption. Dr. Koren…
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🎙The Dual Role of Clinicians as Researchers Ep. 272
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26:58Send us a text Rheumatologist Dr. Manish Jain joins Cardiologist Dr. Michael Koren as they discuss how performing clinical trials can help physicians become more holistic and knowledgeable, and how the process can result in better care for patients. In this conversation, the principal investigators explore Dr. Manish's journey as a clinician and in…
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🎙 Patents and the Physician Inventor Ep. 271
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36:23Send us a text Dr. Dan Schlager, who started his career as an ER physician, joins Dr. Michael Koren to talk about his life path as a physician inventor who transformed emergency response through an innovative GPS technology. Dr. Schlager also talks about other inventions like a lightning-proof shirt, and the legal and bureaucratic process of gettin…
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Send us a text Dr. Michael Koren joins Kevin Geddings as they explore the history and significance of clinical trial integrity over the last 50 years. Dr. Koren brings up the story of Dr. David Baltimore, who's test results on viruses were questioned and who's vigilance helped establish the rigorous standards we see today. It highlights the importa…
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Send us a text On this episode, Medicare and insurance expert Andy Stansfield joins Dr. Michael Koren to review the differences between traditional Medicare and Medicare Advantage. Andy reveals the intricacies of Medicare's components - Parts A, B, C, and D - and explains how the government collaborates with private insurance companies to manage Me…
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🎙 Keystone Habits to Fight Obesity Ep. 268
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32:49Send us a text In this episode, Obesity, Lifestyle, and Pediatric Specialist Dr. Randolph Nunez joins Cardiologist and Clinical Researcher Dr. Michael Koren as they discuss the approaches to managing obesity, particularly in children and adolescents. Dr. Nunez talks about Keystone Habits like sleep, and how tackling those habits are the key to sust…
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🕗 Chief Superbowl Predictions Couldn’t Beat a Clinical Trial Ep. 267
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7:29Send us a text On this week’s MedEvidence Monday Minute, Dr. Michael Koren and Kevin Geddings discuss the superbowl and how the predictions around the outcome - based on past experiences - were no substitute for knowing how the actual game would turn out. They relate this to clinical trials, where a hypothesis can sound sensible and have logical un…
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🎙 The Snowball Effect of Chronic Cough Ep. 266
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26:06Send us a text Join Pulmonologist Dr. Mitchell Rothstein and Allergist and Immunologist Dr. Steve Dorman as they explore the violent activity that can project particles at 100 miles an hour out of your mouth: coughing! The doctors explain the varied approaches doctors take when trying to find the cause of a cough and what happens inside the body to…
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🎙 Does Artificial Intelligence Need to Undergo Clinical Trials? Ep. 265
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44:42Send us a text Technology like Artificial Intelligence (AI) is being integrated more and more into our lives. It's fast, convenient, and can be used at home to gather more health data than ever. But how do we know if the benefits of these technologies outweigh potential risks and pitfalls? Dr. Mike Hafran joins Dr. Michael Koren to discuss how clin…
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🕗 A New Era in Pain Relief Medication Ep. 264
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8:01Send us a text This episode focuses on the FDA's approval of Journavx, a new class of pain medication that offers an alternative to traditional narcotics like OxyContin. Listeners learn about the significance of clinical trials, patient involvement, and the evolution of pain management strategies while emphasizing the need for informed discussions …
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🎙 The Evolving Heart Health Landscape Part 2 Ep. 263
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16:45Send us a text In this second and final part of this series, Dr. Michael Koren and Dr. Seth Baum discuss the importance of patient retention in cardiovascular clinical trials. They highlight how participants in these trials, even those on placebos, often experience better health outcomes due to increased medical attention. They stress the need for …
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🎙 The Evolving Heart Health Landscape Part 1 Ep. 262
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15:35Send us a text The trajectory for those with cardiovascular disease has changed drastically in the past few decades. Cardiologists Michael Koren and Seth Baum discuss the amazing 60% drop in cardiovascular mortality since the 1980's and the worrying rebound in heart-related mortality starting around 2012. They dissect various influences for both of…
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Send us a text Dr. Michael Koren reflects on his interview with Dr. Anthony Fauci with Kevin Geddings. This episode explores Dr. Fauci's history in public health and his life after exiting the government sphere. Dr. Koren and Kevin Geddings also highlight the importance of acknowledging uncertainties in science, and how other fields don't always ha…
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🎙 Hero or Villain? Dr. Tony Fauci Speaks with MedEvidence Ep. 260
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41:42Send us a text Join Dr. Anthony Fauci and Dr. Michael Koren as they discuss the public health events that have punctuated Dr. Fauci's life. The doctors discuss the difficulties of the HIV epidemic in the 1980's and how Dr. Fauci's early career decision to pursue this emerging threat helped inform and prepare him for the COVID-19 pandemic. Doctors K…
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🎙Alcohol Warning Labels: Do the Data Support the Surgeon General's Recommendation? Ep. 259
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32:52Send us a text Recent guidelines from the Surgeon General indicate that even moderate alcohol consumption poses significant health risks, particularly increasing the likelihood of several cancers. In this episode, cardiologist Dr. Michael Koren and GI specialist Dr. Bharat Misra analyze the data on alcohol and if it aligns with the Surgeon General'…
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🕗 Clinical Research: Consistency in a Changing Healthcare Landscape Ep. 258
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8:52Send us a text On this week's Monday Morning Minute, Dr. Michael Koren and Kevin Geddings discuss the worry uncertainty brings in a changing government landscape and how this affects healthcare. They discuss the stress of not knowing what to expect with competing visions from the incoming administration and how the structure of clinical research tr…
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🎙 Starting a Clinical Research Site After COVID-19 Ep 267
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15:02Send us a text Dr. Michael Koren sits down with Alexandria Clark and Anna Fehr of One of a Kind (1-OAK) Clinical Research to discuss their bold decision to launch a clinical research company in 2021, shortly after the disruptions caused by the COVID-19 pandemic. Dr. Koren reflects on how the pandemic reshaped the clinical research landscape, forcin…
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🕗 Checking your Numbers for the New Year Ep 266
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7:23Send us a text Cardiologist and research scientist with ENCORE Research Group, Dr. Michael Koren highlights the importance of monitoring your key health numbers with Kevin Geddings. The two talk about the importance of checking weight, cholesterol, and blood pressure, emphasizing consistency in measurement practices for accurate tracking. They disc…
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🎙Beyond Cholesterol: Inflammation and Heart Health Part 2 Ep 265
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12:32Send us a text Join Dr. Koren and Dr. Ridker for part 2, as they examine the effects of silent inflammation on heart health, emphasizing the importance of understanding specific body signals and the biomarker hsCRP. They also discuss the utility of hsCRP testing as a vital marker for predicting cardiovascular risk due to silent inflammation. The do…
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🎙 Beyond Cholesterol: Inflammation and Heart Health Part 1 Ep 264
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27:24Send us a text Dr. Michael Koren welcomes Dr. Paul Ridker, the leading expert in inflammation and cardiovascular disease, Professor of Medicine at Harvard University, and director of the Center for Cardiovascular Disease Prevention at Brigham and Women's Hospital. Dr. Ridker explains how his career began with challenging traditional medical assumpt…
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🕗 Should We Require Warning Labels on Alcohol in the US? Ep 263
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9:06Send us a text Last week the Surgeon General of the United States, Vivek Murthy, urged congress to pass a law requiring warning labels on alcohol showing the link between even light drinking and gastrointestinal cancers, but is this a good idea? Dr. Michael Korn talks with Kevin Geddings to discuss the balance between the gastrointestinal risks ass…
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🎙 The Pathway to Public Health with Jerome Adams Ep. 262
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24:26Send us a text This episode of MedEvidence! features a compelling discussion between cardiologist and medical researcher Dr. Michael Koren and 20th U.S. Surgeon General Dr. Jerome Adams. Dr. Adams shares his unique journey from growing up in rural Maryland to becoming the nation's top doctor, highlighting the role of personal experience in shaping …
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🎙 Good Clinical Practice is a Good Patient Experience Part 2 Ep. 261
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21:15Send us a text Unlock the secrets to successful clinical trials with Dr. Michael Koren and Doug Denham in part 2 of this podcast. The doctors explore participant retention strategies that make a difference to science and to patients. From obesity studies to cholesterol conditions, Drs. Koren and Denham share their experiences with keeping participa…
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🕗 How Clinical Research Can Help Keep New Year's Resolutions Ep. 260
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8:54Send us a text Dr. Michael Koren and Kevin Geddings discuss New Year’s health resolutions and how clinical research can help achieve them. The conversation highlights the ancillary benefits of participating in research, including expert guidance, hands-on care, and reinforced healthy habits. Dr. Koren also explains that exercising regularly, managi…
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