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π« Foxglove, Frailty, and HFrEF β Digitoxin in Advanced Heart Failure
Manage episode 503362835 series 2740117
Content provided by MasterMedFacts LLC and RR Baliga MD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MasterMedFacts LLC and RR Baliga MD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
π¨ New RCT Alert from the NEJM!
Can an old π make a comeback in modern π failure care?
π The DIGIT-HF trial showed that digitoxin, a cardiac glycoside with hepatic clearance, reduced the combined endpoint of all-cause death or HF hospitalization in HFrEF patients on contemporary guideline-directed therapy β including ARNI, beta-blockers, MRAs & SGLT2i.
π©Ί HR = 0.82; p = 0.03 π
π©ββοΈ Safe in CKD, consistent benefit in women.
β οΈ Serious AEs slightly higher (4.7% vs 2.8%)
π₯ NNT = 22.
π‘Is it time to reconsider digitoxin in advanced HFrEF?
#CardioTwitter #HFrEF #HeartFailure #Digitoxin #NEJM #Cardiology #SGLT2i #GuidelineTherapy
673 episodes
Share
Manage episode 503362835 series 2740117
Content provided by MasterMedFacts LLC and RR Baliga MD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MasterMedFacts LLC and RR Baliga MD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
π¨ New RCT Alert from the NEJM!
Can an old π make a comeback in modern π failure care?
π The DIGIT-HF trial showed that digitoxin, a cardiac glycoside with hepatic clearance, reduced the combined endpoint of all-cause death or HF hospitalization in HFrEF patients on contemporary guideline-directed therapy β including ARNI, beta-blockers, MRAs & SGLT2i.
π©Ί HR = 0.82; p = 0.03 π
π©ββοΈ Safe in CKD, consistent benefit in women.
β οΈ Serious AEs slightly higher (4.7% vs 2.8%)
π₯ NNT = 22.
π‘Is it time to reconsider digitoxin in advanced HFrEF?
#CardioTwitter #HFrEF #HeartFailure #Digitoxin #NEJM #Cardiology #SGLT2i #GuidelineTherapy
673 episodes
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Similar to Dr RR Baliga's "Got Knowledge Doc" Podkast
Help me fill in the blanks of the practice of ED Critical Care. In this podcast, we discuss all things related to the crashing, critically ill patient in the Emergency Department. Find the show notes at emcrit.org.
…
continue reading
We take a critterβs eye view to explore how animal behavior parallels humans. Join comedians and science-lovers as we get inside the minds of animals
…
continue reading
Emergency Medicine Cases β Where the Experts Keep You in the Know. For show notes, quizzes, videos and more learning tools please visit emergencymedicinecases.com
…
continue reading
Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldnβt lie? Could there ever be a fecal transplant black market? (Complicated, it wouldnβt, and yes, respectively, in case youβre curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
…
continue reading
Whether the topic is popcorn or particle physics, you can count on BrainStuff to explore -- and explain -- the everyday science in the world around us.
…
continue reading
The Science Show gives Australians unique insights into the latest scientific research and debate, from the physics of cricket to prime ministerial biorhythms.
…
continue reading
The kickass science and technology radio show that delivers an irreverent look at the week in science and technology.
…
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On Advances in Care, epidemiologist and science communicator Erin Welsh sits down with physicians from NewYork-Presbyterian hospital to discuss the details behind cutting-edge research and innovative treatments that are changing the course of medicine. From breakthroughs in genome sequencing to the backstories on life-saving cardiac procedures, the work of these doctors from Columbia & Weill Cornell Medicine is united by a collective mission to shape the future of health care and transform t ...
…
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