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📊 Polygenic Risk Scores, 💉 Biomarkers, ❤️ Prevention: A New Era in CAD Prediction

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Manage episode 494823672 series 2740117
Content provided by MasterMedFacts LLC and RR Baliga MD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MasterMedFacts LLC and RR Baliga MD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.

🚨 New Insights on Heart Attack Risk! 🧬❤️

A must-read from Circulation: Genomic and Precision Medicine—Bhattacharya et al. show that Polygenic Risk Score (PRS) rivals traditional giants like hypertension in predicting MI! 💥

📊 With an R² loss of 12.4% and PAR of 38.4%, PRS isn’t just academic—it’s actionable. Add in hsCRP and Lp(a), and we’re entering a new era of CAD risk stratification.

🔍 From base to full model:

➡️ R²: 0.021 → 0.053

➡️ C-statistic: 0.65 → 0.73

➡️ PAR: 84.3%

Let’s embrace the fusion of clinical + genetic + biomarker data to better prevent cardiovascular disease. 🧠💡 #Cardiology #Genomics #PrecisionMedicine #CAD #PRS #RiskPrediction #Circulation #HeartHealth #FutureOfMedicine #Biomarkers #PreventionIsPower

  continue reading

575 episodes

Artwork
iconShare
 
Manage episode 494823672 series 2740117
Content provided by MasterMedFacts LLC and RR Baliga MD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MasterMedFacts LLC and RR Baliga MD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.

🚨 New Insights on Heart Attack Risk! 🧬❤️

A must-read from Circulation: Genomic and Precision Medicine—Bhattacharya et al. show that Polygenic Risk Score (PRS) rivals traditional giants like hypertension in predicting MI! 💥

📊 With an R² loss of 12.4% and PAR of 38.4%, PRS isn’t just academic—it’s actionable. Add in hsCRP and Lp(a), and we’re entering a new era of CAD risk stratification.

🔍 From base to full model:

➡️ R²: 0.021 → 0.053

➡️ C-statistic: 0.65 → 0.73

➡️ PAR: 84.3%

Let’s embrace the fusion of clinical + genetic + biomarker data to better prevent cardiovascular disease. 🧠💡 #Cardiology #Genomics #PrecisionMedicine #CAD #PRS #RiskPrediction #Circulation #HeartHealth #FutureOfMedicine #Biomarkers #PreventionIsPower

  continue reading

575 episodes

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