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๐ง REBOOTing Beta-Blockers โ No Gains โ๏ธ After Modern MI ๐
Manage episode 503582562 series 2740117
๐ซ๐ Should We Rethink Beta-Blockers Post-MI?
In the landmark REBOOT trial (NEJM, 2025), beta-blockers failed to reduce mortality, reinfarction, or heart failure hospitalizations in post-MI patients with preserved ejection fraction (>40%).
๐ก A modern, pragmatic trial across 109 centers (Spain + Italy ๐ช๐ธ๐ฎ๐น) with 8438 patients โ shaking the foundation of our long-held post-MI practices.
๐ฉโโ๏ธ Signals of potential harm in women and STEMI subgroups raise questions, not answers.
๐ Should guidelines change? Or should practice just evolve?
#Cardiology #REBOOTTrial #BetaBlockers #NEJM #PrecisionMedicine #MedicalEducation #HeartAttack #LVEF #Guidelines #ClinicalTrials #InternalMedicine #EvidenceBasedMedicine #Revascularization
673 episodes
Manage episode 503582562 series 2740117
๐ซ๐ Should We Rethink Beta-Blockers Post-MI?
In the landmark REBOOT trial (NEJM, 2025), beta-blockers failed to reduce mortality, reinfarction, or heart failure hospitalizations in post-MI patients with preserved ejection fraction (>40%).
๐ก A modern, pragmatic trial across 109 centers (Spain + Italy ๐ช๐ธ๐ฎ๐น) with 8438 patients โ shaking the foundation of our long-held post-MI practices.
๐ฉโโ๏ธ Signals of potential harm in women and STEMI subgroups raise questions, not answers.
๐ Should guidelines change? Or should practice just evolve?
#Cardiology #REBOOTTrial #BetaBlockers #NEJM #PrecisionMedicine #MedicalEducation #HeartAttack #LVEF #Guidelines #ClinicalTrials #InternalMedicine #EvidenceBasedMedicine #Revascularization
673 episodes
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