Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
…
continue reading
Content provided by Gil Blander PhD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Gil Blander PhD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
Similar to Longevity by Design
Emergency Medicine Cases – Where the Experts Keep You in the Know. For show notes, quizzes, videos and more learning tools please visit emergencymedicinecases.com
…
continue reading
Come dive into one of the curiously delightful conversations overheard at National Geographic’s headquarters, as we follow explorers, photographers, and scientists to the edges of our big, weird, beautiful world. Hosted by Peter Gwin and Amy Briggs.
…
continue reading
Help me fill in the blanks of the practice of ED Critical Care. In this podcast, we discuss all things related to the crashing, critically ill patient in the Emergency Department. Find the show notes at emcrit.org.
…
continue reading
The BMJ brings you interviews with the people who are shaping medicine and science around the world.
…
continue reading
Concise summaries of everything published in the latest weekly issue of the New England Journal of Medicine (NEJM). NEJM publishes new medical research findings, review articles, and editorial opinion on topics of importance to biomedical science and clinical practice.
…
continue reading
T
There’s a Better Way: Smart Talk on Healthcare and Technology
1
There’s a Better Way: Smart Talk on Healthcare and Technology
Surescripts
12k
30
The American healthcare system is one of the most innovative in the world. But it’s also riddled with complex challenges, such as access to affordable medications, inefficiency and administrative burdens, and communication barriers between providers. There’s clearly a better way—and at Surescripts, we have a unique sightline into what that may be. In this series, host Melanie Marcus, Chief Marketing Officer of Surescripts, sits down with today’s most inspiring and innovative leaders in healt ...
…
continue reading
Science Friction's latest series is: Cooked. We dig into food science pickles. Why are studies showing that ice cream could be good for you? Do we really need as many electrolytes as the internet says? And why are people feeling good on the carnivore diet? Nutrition and food scientist Dr Emma Beckett takes us through what the evidence says about foods like meat, ice cream and potatoes — and unpicks why nutrition studies can be so conflicting and confusing. All six episodes of Cooked are avai ...
…
continue reading
DNA science. Artificial intelligence. Smartphones and 3D printers. Science and technology have transformed the world we live in. But how did we get here? It wasn’t by accident. Well, sometimes it was. It was also the result of hard work, teamwork, and competition. And incredibly surprising moments. Hosted by bestselling author Steven Johnson (“How We Got To Now”), American Innovations uses immersive scenes to tell the stories of the scientists, engineers, and ordinary people behind the great ...
…
continue reading
Let’s Drone Out is a light-hearted and chatty drone focused podcast. Recorded live and interactively every Thursday 8-9 pm UK time on YouTube, come join the interactive chat. Jack and his wife Tony, as well as the rest of the LDO crew are here to bring noobs and pros together. Tune in every Thursday at 8:00PM UK time for the latest on tech, events, news, interviews and a behind the scenes look into the hobby. LEGAL NOTICE: Any views expressed by any guests on this show are personal and may ...
…
continue reading
Player FM - Podcast App
Go offline with the Player FM app!
Go offline with the Player FM app!
))
Longevity by Design
Mark all (un)played …
Manage series 2955924
Content provided by Gil Blander PhD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Gil Blander PhD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
Longevity by Design is your go-to podcast for unlocking the secrets to a longer, healthier life. Hosted by Dr. Gil Blander, a renowned scientist and entrepreneur in the fields of aging, nutrition, and personalized health, this show dives into cutting-edge research and practical strategies for optimizing your healthspan and lifespan.
In each episode, Dr. Blander sits down with leading longevity and health scientists to explore how we can live better, longer lives. From unpacking complex scientific concepts to sharing the latest advancements in aging research, Longevity by Design offers science-backed insights and actionable advice to help you add years to your life—and life to your years.
Dr. Blander is the founder and Chief Scientific Officer of InsideTracker, a healthspan company that leverages blood tests, DNA analysis, fitness tracker data, and other biomarkers to deliver personalized health recommendations. With a Ph.D. in biology from the Weizmann Institute of Science and postdoctoral research at MIT, Dr. Blander brings decades of expertise and passion to every conversation.
Tune in to Longevity by Design and discover how to live a longer, healthier, and more vibrant life.
85 episodes
Share
Mark all (un)played …
Manage series 2955924
Content provided by Gil Blander PhD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Gil Blander PhD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
Longevity by Design is your go-to podcast for unlocking the secrets to a longer, healthier life. Hosted by Dr. Gil Blander, a renowned scientist and entrepreneur in the fields of aging, nutrition, and personalized health, this show dives into cutting-edge research and practical strategies for optimizing your healthspan and lifespan.
In each episode, Dr. Blander sits down with leading longevity and health scientists to explore how we can live better, longer lives. From unpacking complex scientific concepts to sharing the latest advancements in aging research, Longevity by Design offers science-backed insights and actionable advice to help you add years to your life—and life to your years.
Dr. Blander is the founder and Chief Scientific Officer of InsideTracker, a healthspan company that leverages blood tests, DNA analysis, fitness tracker data, and other biomarkers to deliver personalized health recommendations. With a Ph.D. in biology from the Weizmann Institute of Science and postdoctoral research at MIT, Dr. Blander brings decades of expertise and passion to every conversation.
Tune in to Longevity by Design and discover how to live a longer, healthier, and more vibrant life.
85 episodes
All episodes
×
L
Longevity by Design
1 AI, LLMs & The Future of Longevity: Unlocking Healthspan Innovations with Dr. Eran Segal 1:01:54
1:01:54 
Play Later 
Play Later 
Lists 
Like 
Liked1:01:54
Play Later Play Later Lists Like LikedIn this episode of Longevity by Design, host Dr. Gil Blander welcomes Dr. Eran Segal, Professor at the Weizmann Institute of Science, to explore the intersection of artificial intelligence (AI) and personalized health. The conversation dives into how AI and machine learning are transforming our understanding of nutrition, disease prediction, and overall longevity. Eran provides a clear overview of AI, machine learning, and deep learning, explaining how these technologies can be applied to various health domains. Eran discusses the potential of AI agents in healthcare, such as scheduling appointments, managing medications, and even creating personalized dietary recommendations. He highlights the importance of data in training AI models, noting that the healthcare industry lags behind in publicly available and diverse data sets. The 10K Initiative, a project Eran leads, aims to address this issue by collecting comprehensive data on individuals to build more holistic AI models for personalized health. Gil and Eran consider the future, envisioning AI-powered digital twins that can simulate the impact of lifestyle changes on disease development. While AI offers exciting possibilities, Eran cautions against over-reliance, emphasizing the need for continued human oversight and validation. He reiterates that the foundation of longevity still relies on simple habits: sleep well, eat well, and exercise regularly. Guest-at-a-Glance 💡 Name: Dr. Eran Segal 💡 What they do: Professor 💡 Company: Weizmann Institute of Science 💡 Noteworthy: Computional biologist revolutionizing precision medicine with AI and personalized nutrition. 💡 Where to find them: LinkedIn Episode highlights: Meet Dr. Eran Sega: 00:01:19 Eran's Journey to Becoming a Scientist: 00:02:25 Understanding Personalized Nutrition: 00:04:40 The Link Between Nutrition and Longevity: 00:07:02 Introduction to AI and Machine Learning: 00:08:07 Deep Learning and Generative Models Explained: 00:10:09 The Revolution of Large Language Models (LLMs): 00:13:42 Practical Use Cases of AI Tools: 00: 19:12 The Future of Programming with AI: 00:23:54 The Rise of AI Agents: 00:28:20 AI in Health and Wellness: 00:29:27 Exploring the Best Uses of LLM and ChatGPT: 00:33:23 Real-World Examples of LLM Applications: 00:34:23 Limitations and Risks of LLM Technology: 00: 36:08 Comparing ChatGPT with Other LLM Tools: 00:39:01 Generative AI in Healthcare: Applications and Limitations: 00:39:57 The 10K Initiative: Revolutionizing Health Data: 00:45:31 Future Applications of LLM in Personalized Health: 00:49:19 Looking Ahead: The Future of AI and Healthcare: 00:56:11 Key Takeaways for Health and Longevity: 00:58:10 For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast…
L
Longevity by Design
1 GLP-1, Wearables & Longevity: What You Need to Know – AMA with Gil & Ashley 49:25
49:25 Play Later Play Later Lists Like Liked49:25
Play Later Play Later Lists Like LikedDr. Gil Blander and Ashley Reaver dive into the science behind GLP-1 agonists, a class of drugs originally developed for type 2 diabetes but now widely used for weight management and longevity. They explore how these medications work, their effects on appetite, metabolism, and inflammation, and why they might be a game-changer for cardiovascular health, brain function, and fertility. While promising, they emphasize the importance of long-term research and consulting with medical professionals before considering these treatments. The conversation shifts to the role of wearables in health tracking. Gil shares insights on devices like the Apple Watch, Oura Ring, and Whoop, highlighting their capabilities in tracking sleep, fitness, illness detection, and fall prevention—especially for older adults. They break down how different wearables cater to specific needs and the future of personalized health monitoring. As the science of longevity evolves, Gil and Ashley stress the importance of staying informed, making data-driven decisions, and using technology wisely. Whether through cutting-edge pharmaceuticals or smart wearables, optimizing health is now more accessible than ever. Host-at-a-Glance 💡 Name: Gil Blander 💡What he does: Founder and CSO 💡Company: InsideTracker Host-at-a-Glance 💡 Name: Ashley Reaver 💡What she does: Lead Nutrition Scientist 💡Company: InsideTracker Episode highlights: [00:00:00] Introduction [00:02:02] Understanding GLP-1 Hormones [00:04:26] GLP-1 Receptor Agonists: Mechanism and Benefits [00:06:50] Impact of GLP-1 on Weight and Health [00:21:16] Side Effects and Considerations of GLP-1 Agonists [00:26:31] The Future of GLP-1 Agonists [00:34:54] Exploring Wearables for Health [00:36:08] Choosing the Right Wearable [00:40:29] Wearables for Detecting Illness and Falls [00:47:12] Conclusion and Final Thoughts Key Insights GLP-1 Agonists: A Breakthrough for Weight and Metabolic Health GLP-1 agonists, originally developed for type 2 diabetes, have become a game-changer for weight loss, appetite control, and longevity. These drugs mimic natural gut hormones that regulate hunger and insulin secretion, helping people feel full longer and stabilizing blood sugar levels. Studies show that GLP-1 agonists can reduce body weight by up to 25%, a level comparable to bariatric surgery. Beyond weight management, these drugs may lower inflammation, improve cardiovascular health, and even reduce the risk of certain cancers. However, long-term use is likely necessary, as stopping the medication often leads to weight regain. Gil and Ashley emphasize the importance of medical supervision and highlight ongoing research into how GLP-1 impacts cognitive function and fertility. Wearables: The Future of Personalized Health Tracking Wearables are reshaping how individuals monitor their health from fitness to disease prevention. Gil and Ashley break down Apple Watch, Oura Ring, and Whoop, each catering to different needs. Apple Watch excels at fall detection and emergency response, making it ideal for older adults. Oura Ring provides early illness detection through temperature and heart rate variability tracking. Whoop is favored by athletes for its detailed recovery insights and sleep monitoring. Wearables aren’t just for data collection—they drive behavior change, encouraging users to improve sleep, exercise, and stress management. With AI-driven health coaching on the rise, the hosts predict that wearables will play a central role in proactive healthcare and longevity strategies. For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast…
L
Longevity by Design
1 Muscle, Longevity, and the Power of Protein with Dr. Gabrielle Lyon 1:18:38
1:18:38 Play Later Play Later Lists Like Liked1:18:38
Play Later Play Later Lists Like LikedIn this episode of Longevity by Design, host Dr. Gil Blander welcomes Dr. Gabrielle Lyon, a board-certified family physician and New York Times bestselling author of Forever Strong. Gabrielle discusses the growing epidemic of sarcopenia, the loss of muscle mass and strength, accelerated by the use of GLP-1 medications. She emphasizes the importance of muscle health for overall longevity and introduces the concept of "muscle span." Gil and Gabrielle explore the critical role of skeletal muscle as a metabolically active organ, its impact on longevity, and the best ways to build and maintain muscle throughout life. They delve into the public's misconception of prioritizing today's needs over tomorrow's health, highlighting the need for preventative measures like strength training. The conversation touches upon the complexities of protein consumption, emphasizing the importance of meeting daily protein goals and the often-overlooked nutritional needs for healthy aging. Finally, they address common misconceptions regarding hormone replacement therapy and the importance of prioritizing muscle-centric medicine. This episode offers actionable insights and valuable knowledge for anyone seeking to optimize their health and longevity through a deeper understanding of muscle health. Guest-at-a-Glance 💡 Name: Dr. Gabrielle Lyon 💡 What they do: N/A 💡 Company: Dr. Gabrielle Lyon 💡 Noteworthy: Physician and New York Times bestselling author specializing in muscle-centric medicine and longevity. 💡 Where to find them: LinkedIn , Instagram Episode highlights: [01:09] Meet Dr. Gabrielle Lyon [06:09] The Importance of Muscle Health [09:37] Writing and Impact of 'Forever Strong' [14:45] The Role of Skeletal Muscle [21:54] Building and Maintaining Muscle [26:40] The New Epidemic: Muscle Loss [30:22] Optimizing Health with InsideTracker [39:41] The Importance of Healthy Skeletal Muscle [43:03] The Reality of Aging and Taking Action [45:43] Hormone Replacement Therapy: A Controversial Topic [53:52] Understanding Dietary Protein [01:00:23] Protein Consumption and Distribution [01:03:33] The Role of Animal-Based Products in Human Health [01:15:55] Supplements for Muscle Building and Health [01:17:51] Top Tips for Health Span and Longevity For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast…
L
Longevity by Design
1 The Science, Evolution, and Future of Lifespan and Healthspan with Dr. Michael Ringel 1:12:52
1:12:52 Play Later Play Later Lists Like Liked1:12:52
Play Later Play Later Lists Like LikedOn this episode of Longevity by Design, Dr. Gil Blander speaks with Dr. Michael Ringel, COO of Life Biosciences, about the science of aging and longevity. Michael discusses how evolution influences lifespan and why aging occurs. He explains the trade-off between resource allocation for reproduction versus maintenance and repair within the body. Caloric restriction and its effects on lifespan are explored through an evolutionary lens. Michael highlights the challenges and breakthroughs in longevity research. He touches upon the role of genetics and pharmaceuticals in manipulating lifespan and healthspan. He points to the Pacific rockfish as an example of varying lifespans within a closely related group of species, demonstrating the genetic component of aging. He also notes the impact of Cell reprogramming, referencing a study on how specific Cell reprogramming can regenerate optic nerves. The conversation shifts to the business of longevity, where Michael discusses the increased interest and investments from big pharma and billionaires. He examines the economic benefits of extending healthspan, citing a potential value of $300 trillion from a 10-year healthspan extension in the US alone. Michael and Gil also explore the importance of lifestyle choices for healthy aging, emphasizing diet, exercise, sleep, stress management, and social connections. Guest-at-a-Glance 💡 Name: Dr. Michael Ringel 💡 What they do: COO 💡 Company: Life Biosciences 💡 Noteworthy: Biotechnology COO bridging science and business for longevity breakthroughs. 💡 Where to find them: LinkedIn Episode highlights: [00:00:56] Meet Dr. Michael Ringel [00:02:30] Journey to Becoming a Scientist [00:04:26] Interest in Longevity and Aging [00:07:59] Evolution and Aging [00:21:04] Caloric Restriction and Lifespan [00:25:07] InsideTracker: Personalized Healthspan Optimization [00:26:02] Pharma's Role in Aging Research [00:37:32] Understanding Causality in Medical Research [00:38:09] Challenges of Observational Studies [00:39:40] Experimental Studies and the TAME Trial [00:40:21] Pharmaceutical Incentives and Metformin [00:40:56] Exploring Rapalogs and Patent Issues [00:43:39] Hallmarks of Aging and Future Prospects [00:45:59] Investment in Aging Research [00:52:35] Economic and Social Impacts of Longevity [01:02:30] Practical Tips for Extending Lifespan For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast…
L
Longevity by Design
1 How Long Can Humans Live? Insights from Dr. Jay Olshansky 1:10:08
1:10:08 Play Later Play Later Lists Like Liked1:10:08
Play Later Play Later Lists Like LikedIn this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Jay Olshansky, a leading professor at the University of Illinois Chicago and a renowned expert in aging and biodemography. Together, they delve into the science of longevity, exploring how public health advancements in the 20th century revolutionized life expectancy and what lies ahead in the quest to extend both lifespan and healthspan. Dr. Olshansky unpacks the biological limits of human longevity, shedding light on why life expectancy gains are slowing despite medical advancements. He explains the interplay between genetics, lifestyle choices, and aging, emphasizing how societal factors like inequality and access to healthcare impact longevity outcomes. Key concepts like "life table entropy" reveal why breakthroughs in aging science are essential to push beyond the current boundaries. Tune in to gain actionable insights on diet, exercise, and monitoring health—all crucial for maximizing healthspan, regardless of your genetic blueprint. Guest-at-a-Glance 💡 Name : S. Jay Olshansky, Ph.D. 💡 What he does : Professor at the University of Illinois Chicago School of Public Health 💡 Company : University of Illinois Chicago 💡 Noteworthy: Expert in aging, biodemography, and the biological limits of longevity. 💡 Where to find them : LinkedIn Episode highlights: Introduction: 00:00:00 Dr. Olshansky book: 00:05:40 What was the lifespan 100 years ago and what is it today? : 00:08:00 Average vs longer lifespan: 00:19:00 Death rate at extreme old ages: 00:22:00 What can break the lifespan ceiling?: 00:26:27 What are the chances of someone living up to 120 years old?: 00:28:00 Disparities in Longevity: The Social Determinants of Health: 00:32:00 GLP-1 as a longevity drug: 00:37:00 Why women live longer than men: 00:41:00 How does becoming a U.S. president impact lifespan and healthspan?: 00:46:00 How long can our listeners aim to live?: 00:50:00 What are the key milestones in longevity discoveries over the past few decades?: 00:55:00 What is your top tip for a health span and longevity: 01:15:33 For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast…
L
Longevity by Design
1 Precision Longevity Medicine with Dr. David Barzilai 1:51:36
1:51:36 Play Later Play Later Lists Like Liked1:51:36
Play Later Play Later Lists Like LikedCan personalized medicine unlock the secrets to living longer and healthier lives? In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. David Barzilai, a renowned longevity physician and founder of Barzilai Longevity Consulting, to explore the science of extending healthspan through precision and innovation. Dr. Barzilai shares his journey into biogerontology and longevity science, unpacking key concepts like the hallmarks of aging, the potential of lifestyle interventions, and the translation of findings from animal models to human health. He highlights how evidence-based lifestyle medicine—centered on nutrition, exercise, sleep, and stress management—can be tailored to individual needs using biomarker-driven strategies for maximum impact. The conversation delves into some of the most promising longevity interventions, from gerotherapeutics to cutting-edge supplements. Dr. Barzilai emphasizes the power of personalized approaches in optimizing healthspan and lifespan, offering listeners practical, science-backed insights to take charge of their longevity journey. Engaging and informative, this episode is essential listening for anyone curious about the future of longevity medicine and the innovations shaping how we age. Guest-at-a-Glance 💡 Name: Dr. David Barzilai, MD, PhD 💡What he does: Founder and CEO 💡Company: Healthspan Coaching LLC 💡Noteworthy: Renowned longevity physician integrating science and personalized health strategies. 💡 Where to find them: LinkedIn , Twitter Episode highlights: Introduction: 00:00:00 Dr. Barzilai’s Journey into Science: 00:03:43 The Importance of Translating Science into Practice: 00:10:00 The Role of Social Media in Longevity Science: 00:16:37 Defining Biogerontology: 00:22:32 Understanding the Hallmarks of Aging: 00:24:27 The Role of Lifestyle Medicine in Preventing Premature Mortality: 00:36:13 Caloric Restriction and Its Effects on Lifespan: 00:37:33 Human Trials and the Challenges of Compliance: 00:41:13 The Potential of Rapamycin and mTOR Inhibitors: 00:42:05 The Importance of Lifestyle Medicine: 00:51:25 Precision Medicine: Tailoring Health Interventions: 01:02:56 GLP-1 and Alcohol Absorption: 01:12:30 Exercise and Mortality Reduction: 01:15:33 Biomarkers and Metabolic Health: 01:19:38 Longevity Drugs and Supplements: 01:25:43 Epigenetic Reprogramming and Aging: 01:45:06 For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast…
L
Longevity by Design
1 How Can a Nutrition AI Platform Help Us Live Healthier and Longer Lives with Dr. Dmitriy Richard Starson 56:24
56:24 Play Later Play Later Lists Like Liked56:24
Play Later Play Later Lists Like LikedOn this episode of Longevity by Design, Dr. Gil Blander hosts Dr. Dmitriy Richard Starson, Founder and CEO of Passio, an AI-powered nutrition coaching platform. Dmitriy discusses his career path from astrophysics to the world of nutrition tracking. He explains how his company seeks to make healthy eating more accessible. Passio aims to achieve this through user-friendly technology like food scanning, voice logging, and personalized AI coaching. Dmitriy believes this technology will revolutionize how people approach nutrition. He envisions a future where food tracking is as commonplace as step tracking. This shift, combined with insights from companies like InsideTracker, could lead to personalized nutrition and supplementation plans. Such advances have the potential to slow or even reverse aging and age-related diseases. While acknowledging the influence of the food industry, Dmitriy remains optimistic. He sees a future where individuals have the knowledge and tools to make informed decisions about their health. Through personalized nutrition and data-driven insights, people can optimize their health and work toward increased longevity. Episode highlights: Introduction: 00:00:00 From Astrophysics to Nutrition: An Unlikely Journey?: 00:06:00 The Power of AI in Food Logging: 00:11:00 The "Human" Factor: Addressing Challenges with Data Accuracy: 00:22:00 AI and the Healthcare System: A Balancing Act?: 00:45:00 Top tip to improve healthspan: 00:50:00 We Appreciate You! As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast…
L
Longevity by Design
1 The Path to a 1,000-Year Lifespan with Dr. Aubrey de Grey 53:55
53:55 Play Later Play Later Lists Like Liked53:55
Play Later Play Later Lists Like LikedIn this episode of Longevity by Design, our host Dr. Gil Blander welcomes Dr. Aubrey de Grey, a biomedical gerontologist, to explore the frontiers of aging research and lifespan extension. Dr. de Grey shares his work identifying and addressing the seven major categories of aging-related diseases. He discusses how targeted damage repair offers a promising alternative to traditional methods to slow aging, providing a path to longer, healthier lives. The conversation delves into the hallmarks of aging, their implications for medical research, and the challenges of translating results from animal models to human applications. Dr. de Grey emphasizes the importance of combining multiple interventions, such as senolytics, gene therapy, and stem cell treatments, to achieve significant gains in lifespan. He also shares insights from his work with the LEV Foundation and the Methuselah Foundation. Listeners will gain a deeper understanding of the science behind rejuvenation and the potential for humanity to reach longevity escape velocity within the coming decades. Dr. de Grey underscores the critical role of continued research, innovation, and funding in accelerating progress toward defeating aging-related diseases. Episode highlights: Introduction: 00:00:00 The Seven Hallmarks of Aging: A Foundational Framework: 00:07:00 Challenges in Funding Longevity Research: 00:15:00 Lifestyle, Genetics, and the Limits of Current Longevity: 00:23:00 The Methuselah Foundation and Early Longevity Advocacy: 00:37:00 Top tip to improve healthspan: 00:52:00 We Appreciate You! As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast…
L
Longevity by Design
1 Dietary Changes to Reduce the Risk of Prostate Cancer with Dr. John Erdman 37:09
37:09 Play Later Play Later Lists Like Liked37:09
Play Later Play Later Lists Like LikedOn this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. John Erdman to discuss prostate cancer and the impact of diet on disease progression. John shares his personal connection to this disease and why he’s dedicated his research to understanding dietary interventions. John explains that prostate cancer is often slow-growing, with most men experiencing decades between early mutations and noticeable tumor growth. He stresses the importance of early detection through regular checkups, including digital exams and PSA tests. While the medical community debates the effectiveness of these tests, John advocates for establishing a baseline to monitor for any sudden changes. John's research reveals a strong link between tomato consumption and reduced prostate cancer risk. He believes this protective effect stems from lycopene and its metabolites, which may influence gene expression. John emphasizes that while tomato consumption shows promise, maintaining a healthy weight and regular exercise are equally crucial for long-term health. Episode highlights: Introduction: 00:00:00 The Stages and Progression of Prostate Cancer: 00:06:00 Diagnosing Prostate Cancer: Methods and Considerations: 00:11:00 The Role of Specific Foods in Prostate Cancer Risk Reduction: 00:22:00 Exploring the Link Between Gut Microbes and Prostate Cancer: 00:30:00 Top tip to improve healthspan: 00:34:00 For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast…
L
Longevity by Design
1 Unlocking Longevity: Dr. Jens Juul Holst on GLP-1’s Life-Changing Impact on Metabolic Health 1:23:16
1:23:16 Play Later Play Later Lists Like Liked1:23:16
Play Later Play Later Lists Like LikedIn this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Jens Juul Holst, a renowned Danish physician and physiologist, to discuss GLP-1, a hormone transforming our understanding of metabolic health. Dr. Holst, who discovered and described GLP-1, explains its role as a gut-derived hormone that regulates appetite, insulin secretion, and digestion, offering a groundbreaking approach to managing obesity and type 2 diabetes. The conversation explores how GLP-1 receptor agonists, have evolved into powerful medications. These drugs help patients achieve significant weight loss, reverse diabetes, improve cardiovascular health, reduce inflammation, and potentially enhance cognitive function. Dr. Holst delves into their long-term implications for preventing diabetes, extending health spans, and even reducing the risks of obesity-related cancers and improving fertility. Dr. Holst emphasizes that while GLP-1 offers life-changing benefits, sustainable health still hinges on balanced diets and regular physical activity. This episode provides a fascinating look at the intersection of science, medicine, and lifestyle in promoting longevity. Episode highlights: Introduction: 00:00:00 What is GLP-1: 00:03:00 what is a GLP-1 agonist: 00:04:15 what are the target organs of the GLP-1 agonist?: 00:06:30 what is the effect of the GLP-1 agonist on a diabetic patient? : 00:10:00 What percentage of a diabetic patient on GLP-1 have complete remission: 00:11:30 How long did it take to bring a drug to market from the moment you first discovered it: 00:23:30 What is the GLP-1 effect on cognition and dementia: 00:29:00 GLP-1 effect on kidney diseases: 00:32:00 GLP-1 positive effect on fertility: 00:35:00 GLP-1 positive effect on cancer: 00:37:30 Should a patient be on GLP-1 for life: 00:41:00 GLP-1 related side effects: 00:48:00 GLP-1 effect on resting heart rate: 00:52:30 GLP-1 related side effects: 00:48:00 GLP-1 from Lilly vs novo nordisk: 00:55:00 GLP-1 oral versus the injectable: 00:58:00 GLP-1 effect on lifespan: 01:00:30 GLP-1 effect on lifespan: 01:00:30 What led you to become a scientist: 01:03:00 The story of discovering the GLP-1: 01:04:30 How did you successfully extend the half-life of the GLP-1 agonist: 01:09:00 GLP-1 moving from once a day to once a week: 01:16:00 Top tip to improve healthspan: 01:18:00 GLP-1 Agonists: A Game-Changer for Diabetes and Obesity Dr. Jens Juul Holst explores the revolutionary impact of GLP-1 agonists in treating diabetes and obesity. These medications mimic a natural gut hormone to regulate insulin secretion, appetite, and weight. Through their ability to normalize blood glucose levels and promote significant weight loss, GLP-1 agonists have transformed the lives of patients with type 2 diabetes and obesity. Holst highlights their success in enabling over 50% of diabetes patients to achieve normal glucose levels while addressing the systemic health risks tied to obesity. This innovation represents a monumental leap in metabolic disease management. For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast…
L
Longevity by Design
1 Food Fermentation and Its Effect on Healthspan with Dr. Jacob Allen and Dr. Mike Miller 47:57
47:57 Play Later Play Later Lists Like Liked47:57
Play Later Play Later Lists Like LikedEpisode highlights: Introduction: 00:00:00 Why have you decided to become a scientist: 00:02:30 What is fermentation: 00:07:45 What microbes are involved in fermentation: 00:08:40 How those microbes get into the fermented food: 00:09:35 When the Humankind started to utilize fermentation: 00:11:20 What is the difference between Probiotics and Live Cultures: 00:15:15 What are the benefits of fermented food consumption: 00:17:43 What foods are produced through lactic acid fermentation, and what are the best methods for making them at home: 00:23:10 What is the positive effect of fermented foods on inflammation: 00:29:18 What impact do fermented foods have on longevity: 00:32:10 What are Postbiotics: 00:35:05 Top tip for healthspan: 00:44:20 Not all Fermented Foods Are Equal While many cultures around the world have enjoyed the benefits of fermented foods for centuries, modern consumers need to be savvier about what they’re buying. Just because a food is fermented or contains live cultures doesn’t mean it offers proven health benefits. The term "probiotics" is specifically defined and requires scientific evidence to support health claims, so don’t be afraid to read labels carefully and choose fermented foods backed by research. Lactic Acid Fermentation May Be a Key Player in Health While there are many types of fermentation, lactic acid fermentation, which is responsible for foods like yogurt, kimchi, and sauerkraut, is of particular interest to researchers. Early studies show promising links between consuming lactic acid-fermented foods and positive impacts on gut health, immune function, and even potentially longevity. The specific mechanisms are still being investigated, but it seems these foods offer more than just interesting flavors. Scientists Are Unlocking the Power of Postbiotics Scientists are going beyond probiotics and exploring the potential of “postbiotics” – those beneficial compounds produced by bacteria during fermentation. These metabolites may hold the key to unlocking even more targeted health benefits from fermented foods. Dr. Allen and Dr. Miller’s research on aryl lactates, for instance, suggests that some postbiotics could help modulate immune responses and address inflammation. This area of study is rapidly evolving and offers an exciting frontier in food science and human health. The History and Significance of Fermentation Long before refrigeration, humans discovered the magic of fermentation. This process, dating back thousands of years, involves harnessing the power of microbes to transform food. What began as a way to preserve food has evolved into an art form, with diverse cultures developing unique fermentation traditions that add flavor and depth to their cuisines. "A lot of these fermentation practices keep foods for a much longer period of time without refrigeration and we did not have refrigeration until 100 years ago." - Dr. Jacob Allen Understanding the Difference: Probiotics vs. Live Cultures While often used interchangeably, “probiotics” and “live cultures” have distinct meanings. Probiotics refer to specific strains of live microorganisms scientifically proven to provide health benefits when consumed in adequate amounts. In contrast, “live cultures” indicate the presence of live microbes in food but don't guarantee specific health benefits without further research. “Probiotics are things that have documented clinical evidence. Live cultures, on the other hand, are you eating live microorganisms.” - Dr. Mike Miller We Appreciate You! As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast…
L
Longevity by Design
1 Taste and Smell Preferences and Their Impact on Health with Dr. Yanina Pepino 1:01:46
1:01:46 Play Later Play Later Lists Like Liked1:01:46
Play Later Play Later Lists Like LikedOn this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Yanina Pepino, Professor of Ingestive Behavior at the University of Illinois, to discuss the fascinating link between taste, personal preferences, and long-term health. Yanina's research shows our food environment significantly shapes cravings. This exposure starts as early as the womb, impacting future preferences. Yanina explains that bariatric surgery and GLP-1 medications are powerful tools for weight management. However, she emphasizes the importance of using these interventions as opportunities to adopt healthier eating habits. She highlights the potential of GLP-1 agonists as a treatment for alcohol use disorder, noting their ability to reduce alcohol cravings. The conversation also explores the impact of non-nutritive sweeteners. While generally considered safe, Yanina's research suggests that these sweeteners may have metabolic effects. She encourages listeners to be mindful of their intake and to prioritize natural sugars in moderation. Episode highlights: Introduction: 00:00:00 Why have you decided to be a scientist: 00:03:40 How did you get interested in the taste & smell preference in humans: 00:04:40 The Impact of Maternal Alcohol Consumption During Pregnancy on Newborn Alcohol Preferences: 00:06:00 What you consume during pregnancy can influence your newborn’s preferences: 00:08:00 What Are the Individual Differences in Human Taste: 00:08:20 Do you know if taste perception is influenced by an individual’s specific macro- and micronutrient needs: 00:14:00 What are the effects of bariatric surgery-induced weight loss on flavor perception, eating behavior, and alcohol drinking: 00:16:00 The Impact of GLP-1 Drug Use on flavor perception: 00:26:45 The Impact of lifestyle-related Weight Loss on flavor perception: 00:30:10 The Negative Impact of Alcohol Consumption on Bariatric Surgery Patients: 00:34:30 The potential positive impact of GLP-1 injection on Alcohol Consumption: 00:39:30 What Is the Effect of Non-Caloric Sweeteners on Post-Meal Glucose Spikes and Health: 00:41:30 Bitter taste and why some of us don't like it: 00:52:00 Lessons from the COVID-19 Pandemic on Taste and Smell Perception: 00:54:30 Yanina's top tip for healthspan: 00:42:10 Early Taste Exposure Shapes Lifelong Preferences What we eat during pregnancy and infancy might pre-program a child's future food preferences. Yanina's research reveals that exposure to flavors, even in the womb, can influence what we enjoy eating later in life. This highlights the importance of establishing healthy eating patterns from the very beginning, as those early experiences can have lasting effects. Parents and caregivers have a powerful role in shaping those early preferences for a healthier future generation. Bariatric Surgery and GLP-1 Offer a Chance to "Reset" Both bariatric surgery and GLP-1 medications are not just quick fixes, but opportunities to rewire your relationship with food. While these interventions can significantly impact hunger hormones and promote weight loss, their long-term success relies on behavioral change. Yanina stresses the importance of using this period of altered appetite to explore new, healthier food choices and establish lasting dietary habits. We Appreciate You! As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast…
L
Longevity by Design
1 Ask Me Anything (AMA): Nutrition Deep Dive with Dr. Gil Blander and Ashley Reaver 22:39
22:39 Play Later Play Later Lists Like Liked22:39
Play Later Play Later Lists Like LikedIn this special "Ask Me Anything" episode of the Longevity by Design podcast, Ashley Reaver and Dr. Gil Blander from InsideTracker delve into their latest innovation, the Nutrition Nutrition Deep Dive Solution. After years of research and development, they share the journey of creating a food recognition platform that helps users track their food intake in real time. The goal is to provide users with personalized recommendations for better health and nutrition based on their dietary habits. Dr. Blander explains the challenges that arose over nearly a decade of development, including the complexity of assessing nutritional needs accurately. Through collaboration with experts from Tufts School of Nutrition, InsideTracker has refined its approach, incorporating not only food frequency questionnaires but also real-time food logging. This solution enables users to optimize their intake of macro and micronutrients to improve health outcomes. Ashley emphasizes how this technology allows for a more holistic view of a person's nutrition and its impact on biomarkers, performance, and sleep. With the addition of real-time data, users can now receive tailored insights that align with their fitness and wellness goals. Episode highlights Introduction: 00:00:00 Nutrition Deep Dive Ideation: 00:01:35 Why the Development of the Nutrition Solution Took So Long: 00:02:50 What is the problem we tried to solve: 00:05:25 What is the Value of the Nutrition Deep Dive for the User: 00:07:00 What Are the Expectations for a Nutrition Deep Dive User: 00:09:25 What Does a Nutrition Deep Dive User Receive in Exchange for One Week of Nutrition Logging: 00:11:50 How Often Should Nutrition Deep Dive Users Complete the 7-Day Logging: 00:16:35 Why 7-Days Logging: 00:19:00 Summary 00:21:10 The Evolution of the Nutrition Deep Dive InsideTracker's Nutrition Deep Dive was a decade-long project aimed at solving the challenge of personalized nutrition. Dr. Blander explains that the project began with the realization that no one had figured out how to match the right food with the right person at the right time. The team worked extensively, developing multiple iterations, collaborating with leading scientists, and employing cutting-edge technology, including food recognition platforms and barcode readers. Despite the prolonged process, their persistence led to a comprehensive solution that analyzes user input, such as food consumption and biomarker data, to offer personalized nutritional insights. Food Tracking Technology: A Game-Changer One of the most exciting aspects of InsideTracker’s Nutrition Deep Dive innovation is its food recognition technology. Users can log food through various methods, including scanning barcodes or using their iPhone camera to identify food items. The system is capable of analyzing over 4,000 foods, and the database is continuously expanding. This ability to gather real-time nutrition data revolutionizes how users can assess their diet. When paired with data from fitness trackers, the insights help to better understand the connection between food, sleep, exercise, and overall performance, thus optimizing health. We Appreciate You! As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast…
L
Longevity by Design
1 Unlocking the Secrets of Longevity with Dr. David Sinclair 46:23
46:23 Play Later Play Later Lists Like Liked46:23
Play Later Play Later Lists Like LikedIn this episode of Longevity by Design, our host Dr. Gil Blander speaks with Dr. David Sinclair, a professor of genetics at Harvard Medical School, about the science behind aging and how we can extend both lifespan and healthspan. Dr. Sinclair shares his groundbreaking research on the role of epigenetic changes in aging and the potential to reverse this process. He explains how lifestyle factors, such as diet and exercise, can greatly impact our longevity, and highlights the importance of regularly monitoring health markers like blood glucose and cholesterol. Dr. Sinclair emphasizes the power of technology, including blood tests and personalized health tracking, to help individuals live healthier, longer lives. The conversation also dives into cutting-edge research on longevity drugs and therapies, including gene therapy and reprogramming cells to a younger state. Dr. Sinclair discusses the promising future of treatments aimed at reversing aging and improving the quality of life well into old age. Episode highlights: Introduction: 00:00:00 Why have you decided to be a scientist and not a painter: 00:02:40 What is the difference between healthspan and lifespan: 00:06:00 Can we extend our lifespan: 00:07:10 What should you do to increase your healthspan: 00:09:40 How can we increase our lifespan: 00:14:45 Upcoming Season of David’s Podcast: 00:19:40 GLP-1 as a longevity drug: 00:21:40 The information theory of aging: 00:25:40 How are cells and organisms reprogrammed in the lab: 00:30:10 What are the future opportunities in cell reprogramming: 00:32:50 What is the effect of reprogramming on cancer cells: 00:36:00 What is the effect of reprogramming on senescent cells: 00:38:50 David's top tip for healthspan: 00:42:10 Epigenetic Changes Drive the Aging Process David Sinclair explains that aging is not just wear and tear on the body, but a loss of information within cells. This concept, known as epigenetic aging, involves cells losing their ability to read the right genes at the right time. As cells age, they lose their identity, leading to aging and age-related diseases. The exciting part of this discovery is that these changes may be reversible. Dr. Sinclair’s research focuses on reprogramming cells to restore their youthful function, potentially turning back the biological clock and extending healthspan and lifespan. Lifestyle Choices Are Key to Longevity David Sinclair emphasizes that simple lifestyle choices—like diet, exercise, and regular health monitoring—can have a profound impact on both healthspan and lifespan. He stresses the importance of moving regularly, avoiding processed foods, and maintaining a healthy weight. These actions, along with monitoring key biomarkers such as glucose and cholesterol, are crucial in delaying the onset of age-related diseases. Sinclair’s father, who at 85 is in excellent health, serves as a prime example of how these practices can help people live healthier, longer lives. We Appreciate You! As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast…
L
Longevity by Design
1 The Impact of Artificial Intelligence, Machine Learning, and Large Language Models on Your Health and Wellness With Dr. Renee Deehan 51:26
51:26 Play Later Play Later Lists Like Liked51:26
Play Later Play Later Lists Like LikedIn this episode of Longevity by Design, Dr. Gil Blander talks with Dr. Renee Deehan, Senior Vice President of Science and AI at InsideTracker. They explore the world of artificial intelligence and its applications in health and wellness. Renee explains the differences between AI, machine learning, and large language models (LLMs). She discusses how InsideTracker has developed a specialized LLM called Ask InsideTracker. This tool allows users to interact with a vast knowledge base of health and wellness information. The conversation delves into the potential future applications of AI in personalized health recommendations. Renee emphasizes the importance of data privacy and security when developing these tools. She also shares her perspective on the broader impact of AI in various industries and its potential to enhance decision-making processes. Episode highlights: Introduction: 00:00:00 Defining AI and Machine Learning in Simple Terms: 00:04:00 AI is a branch of computer science: 00:05:00 The Power and Limitations of Large Language Models: 00:08:00 Developing Specialized AI Tools for Health and Wellness: 00:25:00 GPT general foundational model: 00:26:00 The Future of AI in Personalized Health Recommendations: 00:37:00 A balance between nutrition, exercise, and recovery: 00:47:00 The best habit that you can do: 00:48:00 Specialized LLMs Enhance Health Information Accuracy LLMs tailored to specific domains can significantly improve the quality and reliability of information provided to users. By constraining general AI models with specialized knowledge, such as InsideTracker's corpus of health and wellness blog posts, these tools can deliver more accurate and relevant answers. This approach helps filter out noise and misinformation often found in general internet searches. For health and wellness applications, specialized LLMs can offer personalized insights based on high-quality, expert-reviewed content. This method bridges the gap between vast amounts of available information and individual user needs, potentially revolutionizing how people access and understand health-related information. AI in Health: Balancing Personalization and Privacy The integration of AI in health and wellness platforms promises highly personalized recommendations but raises important privacy concerns. As these systems evolve to incorporate individual health data, such as biomarkers and lifestyle information, the potential for tailored advice increases dramatically. However, this advancement requires robust security measures to protect sensitive personal information. The challenge lies in creating AI systems that can access and analyze personal health data while maintaining strict privacy standards. Striking this balance is crucial for the widespread adoption and trust in AI-powered health tools, potentially transforming how individuals manage their health and make lifestyle decisions. Continuous Refinement Key to AI Tool Effectiveness The development and improvement of AI tools, particularly in health and wellness, require ongoing refinement based on user interactions and feedback. This iterative process involves analyzing user queries, identifying areas of improvement, and continuously updating the AI model. By studying how users interact with the tool and the types of questions they ask, developers can enhance the AI's ability to provide relevant and accurate information. This approach ensures that AI tools evolve to meet user needs more effectively over time. The continuous refinement process is crucial for maintaining the tool's reliability and relevance, especially in rapidly evolving fields like health and wellness. For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast…
Welcome to Player FM!
Player FM is scanning the web for high-quality podcasts for you to enjoy right now. It's the best podcast app and works on Android, iPhone, and the web. Signup to sync subscriptions across devices.
Daily Deals
Daily Deals
Similar to Longevity by Design
Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
…
continue reading
Emergency Medicine Cases – Where the Experts Keep You in the Know. For show notes, quizzes, videos and more learning tools please visit emergencymedicinecases.com
…
continue reading
Come dive into one of the curiously delightful conversations overheard at National Geographic’s headquarters, as we follow explorers, photographers, and scientists to the edges of our big, weird, beautiful world. Hosted by Peter Gwin and Amy Briggs.
…
continue reading
Help me fill in the blanks of the practice of ED Critical Care. In this podcast, we discuss all things related to the crashing, critically ill patient in the Emergency Department. Find the show notes at emcrit.org.
…
continue reading
The BMJ brings you interviews with the people who are shaping medicine and science around the world.
…
continue reading
Concise summaries of everything published in the latest weekly issue of the New England Journal of Medicine (NEJM). NEJM publishes new medical research findings, review articles, and editorial opinion on topics of importance to biomedical science and clinical practice.
…
continue reading
T
There’s a Better Way: Smart Talk on Healthcare and Technology
1
There’s a Better Way: Smart Talk on Healthcare and Technology
Surescripts
12k30
The American healthcare system is one of the most innovative in the world. But it’s also riddled with complex challenges, such as access to affordable medications, inefficiency and administrative burdens, and communication barriers between providers. There’s clearly a better way—and at Surescripts, we have a unique sightline into what that may be. In this series, host Melanie Marcus, Chief Marketing Officer of Surescripts, sits down with today’s most inspiring and innovative leaders in healt ...
…
continue reading
Science Friction's latest series is: Cooked. We dig into food science pickles. Why are studies showing that ice cream could be good for you? Do we really need as many electrolytes as the internet says? And why are people feeling good on the carnivore diet? Nutrition and food scientist Dr Emma Beckett takes us through what the evidence says about foods like meat, ice cream and potatoes — and unpicks why nutrition studies can be so conflicting and confusing. All six episodes of Cooked are avai ...
…
continue reading
DNA science. Artificial intelligence. Smartphones and 3D printers. Science and technology have transformed the world we live in. But how did we get here? It wasn’t by accident. Well, sometimes it was. It was also the result of hard work, teamwork, and competition. And incredibly surprising moments. Hosted by bestselling author Steven Johnson (“How We Got To Now”), American Innovations uses immersive scenes to tell the stories of the scientists, engineers, and ordinary people behind the great ...
…
continue reading
Let’s Drone Out is a light-hearted and chatty drone focused podcast. Recorded live and interactively every Thursday 8-9 pm UK time on YouTube, come join the interactive chat. Jack and his wife Tony, as well as the rest of the LDO crew are here to bring noobs and pros together. Tune in every Thursday at 8:00PM UK time for the latest on tech, events, news, interviews and a behind the scenes look into the hobby. LEGAL NOTICE: Any views expressed by any guests on this show are personal and may ...
…
continue reading
Player FM - Podcast App
Go offline with the Player FM app!
Go offline with the Player FM app!
