GLP-1 Fatigue: Why You’re Tired & How to Get Your Energy Back

The Hunter Williams Podcast

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If you’re struggling with fatigue, low motivation, or brain fog while on GLP-1 agonists like tirzepatide or retatrutide, you are NOT alone! I get asked about “GLP-1 fatigue” constantly, and in this video, I dive deep into why so many people experience tiredness on these meds, the science behind it, and—most importantly—what you can do to overcome it and get your energy back.
I cover everything from calorie restriction and dehydration to hormone and mitochondrial slowdown, and even the toxic load released during rapid fat loss. Whether you’re new to GLP-1s or have hit an energy wall, this is the comprehensive review you need!
Timestamps:
0:00 – Intro: Why are GLP-1 users so fatigued?
1:33 – What are GLP-1s, and why do people use them?
2:30 – How common is fatigue on GLP-1s?
3:24 – Who gets prescribed GLP-1s and why fatigue might be worse for some
4:10 – Calorie restriction and appetite suppression
5:43 – Metabolic adaptation: Why your metabolism slows down
6:20 – Nutrient deficiencies and low protein
7:37 – Weight loss itself: Why rapid fat loss can make you feel weak
7:41 – Dehydration and electrolyte imbalances
8:39 – Reduced thirst and GI side effects
9:56 – Blood sugar fluctuations and hypoglycemia
11:03 – Brain effects: Dopamine, mood, and motivation
12:15 – Hormonal changes: Leptin, thyroid, testosterone
13:40 – Neurological factors: GLP-1 in the brain
15:49 – The “detox effect” of rapid fat loss
17:06 – How toxin release and inflammation cause fatigue
18:47 – Mitochondrial slowdown: Why you feel so flat
20:45 – Practical fixes: What to do about GLP-1 fatigue
22:57 – How to eat, hydrate, and adjust your dose
24:15 – Timing your injections and microdosing
25:30 – Circadian rhythm, sunlight, and lifestyle tips
26:42 – Closing thoughts and community feedback
If you’ve experienced fatigue or brain fog on GLP-1s, comment below—share what worked for you! And if you want a deeper dive into peptides, hormones, and biohacking, grab my free peptide cheat sheet in the description and join Fully Optimized Health, the best community for health optimization.
Thank you for being here—I’m grateful for every one of you! If you found this helpful, like, comment, and subscribe for more science-backed content.