Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
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Player FM - Internet Radio Done Right
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Content provided by MasterMedFacts LLC and RR Baliga MD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MasterMedFacts LLC and RR Baliga MD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
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Squid Game: The Official Podcast
Squid Game is back—and this time, the knives are out. In the thrilling Season 3 premiere, Player 456 is spiraling and a brutal round of hide-and-seek forces players to kill or be killed. Hosts Phil Yu and Kiera Please break down Gi-hun’s descent into vengeance, Guard 011’s daring betrayal of the Game, and the shocking moment players are forced to choose between murdering their friends… or dying. Then, Carlos Juico and Gavin Ruta from the Jumpers Jump podcast join us to unpack their wild theories for the season. Plus, Phil and Kiera face off in a high-stakes round of “Hot Sweet Potato.” SPOILER ALERT! Make sure you watch Squid Game Season 3 Episode 1 before listening on. Play one last time. IG - @SquidGameNetflix X (f.k.a. Twitter) - @SquidGame Check out more from Phil Yu @angryasianman , Kiera Please @kieraplease and the Jumpers Jump podcast Listen to more from Netflix Podcasts . Squid Game: The Official Podcast is produced by Netflix and The Mash-Up Americans.…
🥗🧬💊 “Eat Less or Pop a Pill? Rapamycin vs. Metformin
Manage episode 490018456 series 2740117
Content provided by MasterMedFacts LLC and RR Baliga MD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MasterMedFacts LLC and RR Baliga MD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
🔬 New meta-analysis alert! 🧪 Researchers compared rapamycin and metformin to dietary restriction across 167 studies in 8 vertebrate species.
📈 Key finding: Rapamycin mirrors dietary restriction’s longevity benefits—but metformin falls short.
⚠️ High heterogeneity and species bias remind us: translation to human health still needs careful navigation.
🧠 Full of insights for aging science, pharmacology, and precision medicine!
#LongevityScience #Rapamycin #AgingResearch #MetaAnalysis #LifespanExtension #PrecisionMedicine 👩🔬📊🧬
572 episodes
ShareManage episode 490018456 series 2740117
Content provided by MasterMedFacts LLC and RR Baliga MD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MasterMedFacts LLC and RR Baliga MD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
🔬 New meta-analysis alert! 🧪 Researchers compared rapamycin and metformin to dietary restriction across 167 studies in 8 vertebrate species.
📈 Key finding: Rapamycin mirrors dietary restriction’s longevity benefits—but metformin falls short.
⚠️ High heterogeneity and species bias remind us: translation to human health still needs careful navigation.
🧠 Full of insights for aging science, pharmacology, and precision medicine!
#LongevityScience #Rapamycin #AgingResearch #MetaAnalysis #LifespanExtension #PrecisionMedicine 👩🔬📊🧬
572 episodes
All episodes
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1 📊 Polygenic Risk Scores, 💉 Biomarkers, ❤️ Prevention: A New Era in CAD Prediction 4:20
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Play Later Play Later Lists Like Liked🚨 New Insights on Heart Attack Risk! 🧬❤️ A must-read from Circulation: Genomic and Precision Medicine —Bhattacharya et al. show that Polygenic Risk Score (PRS) rivals traditional giants like hypertension in predicting MI! 💥 📊 With an R² loss of 12.4% and PAR of 38.4%, PRS isn’t just academic—it’s actionable. Add in hsCRP and Lp(a), and we’re entering a new era of CAD risk stratification. 🔍 From base to full model: ➡️ R²: 0.021 → 0.053 ➡️ C-statistic: 0.65 → 0.73 ➡️ PAR: 84.3% Let’s embrace the fusion of clinical + genetic + biomarker data to better prevent cardiovascular disease. 🧠💡 #Cardiology #Genomics #PrecisionMedicine #CAD #PRS #RiskPrediction #Circulation #HeartHealth #FutureOfMedicine #Biomarkers #PreventionIsPower…
1 💪🍊 “Flavonoid Fightback: Apigenin Saves Muscle, Not Waistlines” 4:09
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Play Later Play Later Lists Like Liked🚨 New Research Alert! 💡 Just explored a fascinating preclinical study on apigenin 🧪—a flavonoid found in parsley & chamomile 🌿—that prevents muscle loss in aging, obese rats 🐀💪. 📉 While it didn’t stop weight gain or fat buildup, apigenin boosted muscle mass, reduced fibrosis 🦵, and activated anabolic signaling (p70S6K) 🔁. 💊 Could this be a future nutraceutical for sarcopenic obesity and healthy aging? More clinical research needed—but the signal is strong. 🚦 #Apigenin #Flavonoids #Sarcopenia #Obesity #MuscleHealth #Aging #Nutraceuticals #PrecisionMedicine #Geroscience #Phytochemicals 🍊🧬…
1 “Shock, Sync, Save 🫀: 2025 AUC Updates Explained” 4:29
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Play Later Play Later Lists Like Liked🚨 New in 2025! The ACC/AHA Appropriate Use Criteria for ICDs, CRT, and Pacing just got a major upgrade! 🫀📊 Covering 335 real-world scenarios, this document is your go-to guide for when (and when not ) to implant. 💡 What’s 🔥 in the update? ⚡ Leadless & conduction system pacing 🔁 CRT refined for better outcomes 🧠 Smart use in LVADs, post-transplant, & more 👩⚕️ Clinicians: Make device decisions with clarity, confidence, and evidence. 📥 Download our podcast + slides to stay ahead. #Cardiology #ICD #CRT #Pacing #AUC #HeartFailure #EP #PrecisionMedicine #MedEd #2025Guidelines…
1 Dr. RR Baliga’s Philosophical Discourses: : Adi Shankaracharya (India, 788–820 CE) - – Advaita Vedanta Philosopher 3:00
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Play Later Play Later Lists Like Liked🧘♂️📿 Discover the timeless wisdom of Adi Shankaracharya (788–820 CE) — the master of Advaita Vedanta who redefined spirituality with concepts like Atman, Brahman & Sanyasa. His teachings on non-duality still inspire seekers worldwide. 🌍📚 #Philosophy #Vedanta #Spirituality
1 Coronary Plaque Rupture. Erosion. Revelation. 🔬🫀🧠 5:27
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Play Later Play Later Lists Like Liked🫀 New insights from Covani et al. and Ben-Yehuda’s editorial reveal a striking paradox: more cardiovascular risk factors 🔥 = more plaque rupture, but less erosion! 🧊 Using OCT imaging, they show how traditional risks drive inflammatory, rupture-prone plaques , while erosion may follow a different path altogether—less lipid, less inflammation, more mystery. 🧬 🎯 Takeaway: Precision prevention must evolve. Not all plaques (or patients) follow the same script. 🔗 Dive into this convergence of epidemiology & imaging 👉 #PlaqueVulnerability #STEMI #NSTEMI #OCT #Cardiology #Prevention #PrecisionMedicine…
1 🌫️ The Exposome Effect: What’s in Your Air, Food, and Life? 🍔🧪🚦 Everything but DNA — The New Frontier in Health 2:49
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Play Later Play Later Lists Like Liked🌍🔬 What’s shaping your health beyond your genes? Introducing our latest Got Knowledge Doc podcast episode: “Beyond Genes, Beneath the Skin 🧬🌫️” — a deep dive into the exposome , the totality of your environmental exposures from womb to tomb. From microplastics to sleep, PFAS to social stress, we’re mapping the missing link in precision medicine. 🎧 Tune in to explore why the future of health might depend less on your DNA and more on your data trail . 🧠 Prevention. 📊 Policy. 💊 Personalization. #Exposome #PrecisionMedicine #EnvironmentalHealth #PublicHealth #WearableTech #GotKnowledgeDoc…
1 💓 TREGs, Fibrosis & Hope: Rewiring the HCM Heart 3:02
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Play Later Play Later Lists Like Liked🚨 New Insights in Hypertrophic Cardiomyopathy (HCM)! 💓 Groundbreaking research shows that regulatory T cells (TREGs) can reduce fibrosis, suppress inflammation, and even improve heart function in HCM 🧬🛡️ From adoptive TREG transfer to IL-2 therapy, immunomodulation is emerging as a promising strategy alongside genetic and myosin-targeted treatments 💉📉 🧠 A must-read for cardiologists, immunologists & translational researchers! 📄 Wang et al., Sci. Transl. Med. 2025 🔗 #Cardiology #HCM #TREG #Immunotherapy #Fibrosis #PrecisionMedicine #TranslationalScience #HeartFailure #IL2 #CellTherapy…
1 💤🧠 Flush, Sleep, Forget: The Glymphatic Code in Alzheimer’s Disease 2:29
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Play Later Play Later Lists Like Liked🧠💤 Just dropped our latest Got Knowledge Doc podcast: “Flush, Sleep, Forget: The Glymphatic Code in Alzheimer’s Disease” 🧬🎧 We explore how the brain’s nighttime rinse cycle clears toxic proteins like amyloid β and tau—and what happens when that system breaks down. From rodent models to human MRI, it’s a story of sleep, science, and hope. 🌙🔬 Listen in to learn how advancing glymphatic research might open doors to early detection and prevention of Alzheimer’s. 🧪🧩 #AlzheimersDisease #GlymphaticSystem #Neuroscience #SleepScience #BrainHealth #AQP4 #CognitiveDecline #PrecisionMedicine #Neuroimaging #MedicalPodcast 🎙️…
1 Gut Talks to the Heart 🥗💓🧠: The Incretin Connection 4:21
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Play Later Play Later Lists Like Liked🚨 New Podcast Episode! 🎙️ “Gut Talks to the Heart 🥗💓🧠: The Incretin Connection” Did you know that GLP-1 and GIP do far more than control blood sugar? These humble gut hormones orchestrate perfusion, reduce inflammation, protect the brain, heart, kidneys—and may even slow cognitive decline. 💊 From diabetes care to cardio-renal-neuro protection, incretin-based therapies are rewriting the rules of metabolism. 🔗 Tune in to learn how your next meal could be triggering an endocrine symphony. #Cardiology #Endocrinology #Incretins #GLP1 #GIP #Metabolism #Neuroprotection #DiabetesCare #PrecisionMedicine #MedicalPodcast 🎧…
1 👄 Mouths Heal Better: What Your Skin Can Learn from Oral Wounds 3:55
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Play Later Play Later Lists Like LikedExciting new insights from Science Translational Medicine (2025)! Researchers uncovered how the GAS6–AXL–FAK axis determines whether wounds heal with scars or regeneration. 🧬💉 💡 Activating AXL with GAS6 rewires fibrotic healing into scarless repair — especially in the oral mucosa. 💥 Blocking AXL flips the script, leading to fibrosis even in normally regenerative tissues. This could revolutionize how we approach scar prevention and tissue regeneration. 🩹✨ #RegenerativeMedicine #WoundHealing #Fibrosis #AXL #FAK #PrecisionMedicine #GAS6 #scRNAseq #Biotech #Innovation #TranslationalScience…
1 ☕ Evidence Per Cup: Coffee and Cardiovascular Outcomes 4:53
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Play Later Play Later Lists Like Liked☕💓 Is your daily brew helping or harming your heart? New evidence from a comprehensive European Heart Journal review suggests that moderate coffee consumption (1–4 cups/day) is linked to reduced risks of hypertension, type 2 diabetes, coronary artery disease, heart failure, stroke, and even mortality. 🧬 Benefits often persist regardless of caffeine content, and filtered coffee appears safest for lipid profiles. ⚠️ But beware: excessive intake and unfiltered brews may raise LDL. 📊 Great read for clinicians navigating patient questions on coffee and cardiovascular risk. 🔗 #Coffee #Cardiology #CME #HeartHealth #LifestyleMedicine #PreventiveCardiology #EvidenceBasedMedicine…
1 Longevity’s Guardians?: The Brain and Immune System Duo 3:17
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Play Later Play Later Lists Like Liked🧠🧬 New research alert! Plasma proteomics from 44,000+ UK Biobank participants reveals that the brain and immune system are powerful predictors of longevity. A youthful brain and immune system cut mortality risk nearly in half—more so than any other organ. This could reshape how we think about aging, diagnostics, and preventive medicine. 📊 Machine learning + blood proteins = next-gen aging biomarkers. 🔗 Study link: https://doi.org/10.1038/s41591-025-03798-1 #Longevity #Proteomics #BrainHealth #ImmuneSystem #Aging #Biomarkers #PrecisionMedicine #UKBiobank #HealthyAging #Neuroimmunology #PlasmaProteomics #OrganAging…
1 Five to Thrive: Slash Your Cardiovascular Disease Risk ✋🛡️🧬 4:42
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Play Later Play Later Lists Like Liked📣 New insights from a global study on cardiovascular disease! 🌍❤️ Even without traditional risk factors, your lifetime risk of CVD isn’t zero — but midlife action can add a decade or more of healthy life. 🧠💡 Key takeaway: Knowing is not enough — we must apply. 🩺📊✅ #CardiovascularHealth #PreventionMatters #GlobalHealth #PrecisionMedicine #PublicHealth 💪🌎🧬…
🔬 Just read a fascinating News & Views in Nature on how weight loss reshapes adipose tissue beyond just shedding fat! 🧬 Using single-nucleus RNA-seq and spatial profiling, researchers found that bariatric surgery reverses stress, inflammation, and senescence in fat depots—yet some immune memory lingers. 🧠🔥 A compelling case for adipose plasticity—and why cellular “memory” may be the key to sustained metabolic health. 💡💪 #ObesityResearch #AdiposeRemodeling #WeightLossScience #Senescence #PrecisionMedicine #Nature…
🧠💓 Just read a fascinating new study in Cell Metabolism (July 2025): dislocation of hexokinase 1 from mitochondria increases O-GlcNAcylation in endothelial cells — a hidden driver of HFpEF! Reversing this sugar-tagging with OGA overexpression or OGT inhibition restores heart function in mice. Precision metabolism meets cardiology. 🔬❤️🔥 #HFpEF #OGlcNAcylation #EndothelialDysfunction #CardioResearch #MetabolicTherapeutics #CellMetabolism…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 Cats, Dogs, and Clarity 🐕🐈💡: The Cognitive Perks of Pet Ownership 3:34
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Play Later Play Later Lists Like Liked🐾 New Research Alert! 🧠 Owning a dog or cat may do more than warm your heart — it could help preserve your mind ! 🐶🐱 A large 18-year study across Europe found that pet owners experienced slower cognitive decline, especially in memory and verbal fluency. 🧪 No boost seen with fish or birds 🐠🐦, but fur friends = brain gains! 🔗 Let’s rethink aging — with tails, not pills. #HealthyAging #PetScience #CognitiveHealth #Longevity #BrainHealth 🧓💡…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 🧪🛡️ Stroke Shield: How Tirofiban Tips the Scales 3:14
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Play Later Play Later Lists Like Liked🧠✨ New Stroke Breakthrough! The ASSET-IT trial shows that early infusion of tirofiban after thrombolysis significantly boosts recovery in noncardioembolic stroke patients — with 65.9% achieving excellent outcomes at 90 days vs 54.9% with placebo 📈💉 ✅ Improved function ⚠️ Slightly higher bleeding risk 🌏 Study conducted across 38 centers in China 📚 Read the trial in NEJM (July 2025) #Stroke #Tirofiban #Neurology #RCT #PrecisionMedicine #Thrombolysis #CardiovascularResearch…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 🧠 Trinity & Truth: The Theological Legacy of Boethius 📜 2:45
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Play Later Play Later Lists Like Liked📚✨ Just explored Boethius: The Consolation of Philosophy — a timeless journey from despair to divine reason. Written in prison, this masterpiece blends Roman philosophy with Nicene Christian theology, standing firm against Arianism. 🕊️⚖️ 🎧 Listen now: Dr. Baliga’s Got Knowledge Doc Podkast #Boethius #Theology #FaithAndReason #Podcast 💡🎙️📜…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 Exercise Without Exercise? Betaine’s Magic Revealed! 🧘✨🧬” 3:03
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Play Later Play Later Lists Like Liked💡 New Study Alert! 🏃♂️🧪 Kidney-derived betaine mimics long-term exercise—blocking TBK1, reducing inflammation, and reversing aging markers. This multi-omics human + mouse study uncovers betaine as a precision geroprotector for those who can’t hit the gym. 📈 A leap toward exercise mimetics in aging science! #Geroprotection #PrecisionMedicine #ExerciseScience #Betaine 🧬🧓🔥…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 🧪 Reset, Rewind, Rejuvenate: Chemical Reprogramming Against Aging 3:07
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Play Later Play Later Lists Like Liked🧬 Rewinding Cellular Time with Chemistry! 🧪 A groundbreaking study just showed that a two-chemical cocktail (2c) — Tranylcypromine + Repsox — can reverse aging markers in human cells and extend C. elegans lifespan by 42%! 🐛💥 Unlike gene-based reprogramming, this method is safer, scalable, and preserves cell identity. Think of it as “Yamanaka lite” — with big implications for aging and longevity science. 🧠💊 #Longevity #Epigenetics #Rejuvenation #Biotech #AgingResearch #Lifespan…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 From ABI to Amputation: Navigating PAD with Precision 3:32
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Play Later Play Later Lists Like Liked🚶♂️💔 Just recorded a podcast on Peripheral Artery Disease (PAD) – a silent threat affecting 200M+ people worldwide. We unpack the latest 2024 ACC/AHA guidelines: ✅ When to screen 💊 What therapies work 🦿 How to save limbs & lives Tune in to walk away smarter. 👣🎙️ #PAD #Cardiology #Guidelines #Prevention #LimbSalvage…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 Osteoporosis Uncovered: Risk, Resilience, and Recovery 🔍🛡️🔄 4:25
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Play Later Play Later Lists Like LikedJust finished reviewing the latest JAMA 2025 article on osteoporosis by Morin et al. — a must-read for anyone managing bone health in aging adults! 📉 Despite advances, 70% of fractures occur in those without DXA-defined osteoporosis. 💊 Treatment isn’t just about T-scores — it’s about fracture risk, fall prevention, and smart sequencing of antiresorptive and anabolic therapies. 🏋️♀️ Plus, lifestyle matters: resistance training, calcium, vitamin D, and proactive screening save lives. 📈 Fracture Liaison Services (FLS) boost treatment initiation from 17% ➡️ 38%. Let’s bridge the gap between diagnosis and action. 🔗 If you work in internal medicine, endocrinology, geriatrics, or public health — this is worth your time. #Osteoporosis #FracturePrevention #BoneHealth #JAMA2025 #DXA #PrecisionMedicine #HealthyAging…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 🧬 Targeting Aldosterone: A New Shot at Hypertension 🎯💥 3:45
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Play Later Play Later Lists Like Liked🚨 New breakthrough in hypertension care! 💊 The Launch-HTN trial shows lorundrostat — a selective aldosterone synthase inhibitor — significantly lowers systolic BP in patients with uncontrolled or treatment-resistant hypertension. 📉 −16.9 mmHg vs −7.9 mmHg with placebo (P < .001) 🧪 Safe, well-tolerated, and effective across subgroups. A potential game-changer in aldosterone-targeted therapy! 🔄💥 #Hypertension #Cardiology #ClinicalTrials #PrecisionMedicine…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 Diagnose, Personalize, Optimize: The 2025 Diabetes Blueprint 4:19
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Play Later Play Later Lists Like LikedOur latest podcast episode unpacks the 2025 JAMA Review on Type 2 Diabetes 🔬💊 We explore: ✅ New diagnostic strategies ✅ Why GLP-1s & SGLT2is are game-changers ✅ How lifestyle change can lead to remission ✅ Individualizing A1C goals in real-world care 🎙️ Episode Title: “Diagnose, Personalize, Optimize: The 2025 Diabetes Blueprint” 📈 Essential listening for clinicians, educators, and innovators in endocrine & cardiometabolic care. 👉 Tune in now and share with your network! #Type2Diabetes #CardiometabolicCare #GLP1 #SGLT2 #PrecisionMedicine #GotKnowledgeDoc 🎧…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
How we sleep tonight shapes how we move tomorrow! 📉🏃♂️ In a large-scale wearable study (📱WHOOP & Fitbit data from >25,000 adults), researchers found: ✅ Sleeping earlier than usual boosts next-day physical activity ❌ Longer or later sleep = less movement 🔥 Max gains came from consistent sleep duration + early bedtime Let’s rethink our 💤 to power our 💥! 📣 Public health campaigns should promote sleep and exercise together—not in competition. 📄 PNAS, June 2025 | doi: 10.1073/pnas.2420846122 #SleepHealth #PhysicalActivity #WearableTech #Chronobiology #PublicHealth #WHOOP #Fitbit #MVPA #HealthOptimization #BehavioralScience…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 Wrinkle, Rust, and Rewind: 17 Theories of Why We Age 7:32
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Play Later Play Later Lists Like Liked🧬 Curious why we age? 🕰️ From DNA damage to developmental programs gone rogue, this new podcast episode dives deep into 17 theories of ageing — some classic, some controversial. 🔍 We explore wear-and-tear, free radicals, telomeres, mitochondria, stem cell exhaustion, and the rising stars of epigenetic drift and hyperfunction theory. 🎙️ Whether you’re a scientist, clinician, or just fascinated by the biology of time, tune in to uncover what really drives the ageing process—and what might one day slow it down. 🧠 Listen now: “Wrinkle, Rust, and Rewind: 17 Theories of Why We Age” #AgeingScience #Longevity #Geroscience #MolecularBiology #Epigenetics #Senescence #HealthcareInnovation…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 💥 Beyond the Block: Cracking the Code of Chest Pain 🔬❤️ 6:09
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Play Later Play Later Lists Like LikedRefractory Angina: Time to Rethink the Diagnosis 🫀💥 Chest pain that defies stents and statins? It may not be your typical obstructive CAD. This podcast unpacks the redefinition of refractory angina — spotlighting INOCA, CMD, vasospasm, and myocardial bridging 🔬⚙️ We explore PET, CMR, CFVR, and wire-based diagnostics 🔎 — and why a multidisciplinary Angina Heart Team is key to transforming care 👩⚕️👨⚕️🧠 🎧 Listen in as we chart a course from frustration to precision — because even stubborn angina has a story and a solution. #RefractoryAngina #INOCA #CMD #PrecisionMedicine #Cardiology #MedicalPodcast #PETimaging #StratifiedCare #AnginaHeartTeam #GotKnowledgeDoc 🎙️…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
🔬🌍 New insights from Nature Aging : Inflammaging isn’t universal! A fascinating cross-cultural study comparing Italy 🇮🇹, Singapore 🇸🇬, Bolivia 🇧🇴, and Malaysia 🇲🇾 shows that age-related inflammation—long considered a hallmark of aging—may actually be a product of industrialized environments. Populations like the Tsimane (Bolivia) and Orang Asli (Malaysian), despite high infection loads, show minimal correlation between cytokines and age-related disease. 📉 Conclusion: Inflammaging is not destiny—it’s context. 🧪 Read the full study to explore how culture, infection, and environment shape aging biology. #Inflammaging #AgingBiology #GlobalHealth #PrecisionMedicine #Immunology #Epidemiology #NatureAging…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 🧠❤️ Predict. Prevent. Protect: AI’s Lifesaving Role in HCM 3:54
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Play Later Play Later Lists Like Liked🚨 AI vs Sudden Cardiac Death in HCM 🫀🤖 Exciting new study published in Nature Cardiovascular Research showcases MAARS, a multimodal AI model that dramatically improves risk prediction for sudden arrhythmic death in hypertrophic cardiomyopathy patients. 📊 MAARS outperformed current guidelines with AUROC of 0.89 (internal) and 0.81 (external) 🧠 Integrated data: LGE-CMR 🧲, EHR 📋, and echo/CMR reports 💻 ⚖️ Demonstrated fairness across age and sex subgroups 🔍 Transparent predictions via Shapley values and attention heatmaps A leap toward personalized, preventative cardiology 💡🩺 #AI #Cardiology #HypertrophicCardiomyopathy #SuddenCardiacDeath #MachineLearning #PrecisionMedicine #DigitalHealth #MAARS #RiskStratification #HCM…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 💡 Personalized, Precise, Powerful: The Rise of Cancer Vaccines 🧪 4:26
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Play Later Play Later Lists Like Liked“Vax to the Future: Cancer Immunity Revolution 🧬💉” Cancer vaccines are no longer a promise — they’re a precision revolution . From HBV and HPV to cutting-edge mRNA-based neoantigen vaccines, we explore how tumor sequencing + AI + immune checkpoint inhibitors are reshaping oncology. 📈 Real data from trials in melanoma, ccRCC, and pancreatic cancer ⚔️ PD-1 inhibitors meet targeted T cells 🌍 A safer, scalable future for cancer care 🎧 Tune in to Got Knowledge Doc as we decode this game-changing viewpoint from JCI — “Vaccines in Cancer Treatment and Prevention: The Time is Now.” #CancerVaccines #mRNA #Immunotherapy #PrecisionOncology #Neoantigens #Podcast #GotKnowledgeDoc 🎙️…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 🍬 Endothelium Under Attack: The Sweetener-Inflammation Link 2:58
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Play Later Play Later Lists Like Liked🚨 New Findings on Aspartame & Heart Health! 🍬🫀 A groundbreaking study in Cell Metabolism reveals how aspartame, a common artificial sweetener, may worsen atherosclerosis via an insulin-triggered inflammatory pathway involving the CX3CL1-CX3CR1 axis. 🧪 Key insights from mice and monkeys: – Aspartame spikes insulin via vagus nerve stimulation – Elevated insulin boosts CX3CL1 expression in endothelial cells – CX3CL1 recruits inflammatory monocytes ➡️ plaque growth & instability 🧬 Blocking CX3CR1 in monocytes stopped plaque progression entirely. ⚠️ Implications for diabetics, sweetener users, and those at risk of cardiovascular disease are profound. #Atherosclerosis #Aspartame #Cardiology #PrecisionMedicine #Inflammation #Insulin #CX3CL1 #MedicalResearch #Podcast #CardioMetabolism…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 Dr RR Baliga's Philosophical Discourses: Saint Augustine of Hippo (354–430 CE) 2:57
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Play Later Play Later Lists Like LikedSaint Augustine of Hippo (354–430 CE), a prominent theologian, philosopher, and bishop in Roman North Africa, profoundly influenced Western Christianity and philosophy. Known for works like Confessions , The City of God , and On Christian Doctrine , he developed doctrines on original sin, grace, just war, and ecclesiology. His thoughts shaped medieval theology, inspired Protestant Reformers, and continue to impact Christian teachings.…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 Beats, Bytes, Brilliance 🫀💾🌟: The Rise of AI in Echocardiography 3:27
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Play Later Play Later Lists Like Liked🚨 Just out in JAMA ! 💡 PanEcho , a multitask AI model trained on over 1.2 million echo videos, can automate complete echocardiographic interpretation — from LVEF to valvular disease — with diagnostic AUCs up to 1.00 and MAE as low as 4.2%. 🌍 Validated across international cohorts, including point-of-care settings, this tool could redefine access, accuracy, and efficiency in cardiac imaging. 🫀🤖 A major leap toward AI-assisted cardiovascular diagnostics. 🔗 Read the study #AIinMedicine #Cardiology #EchoRevolution #PanEcho #DigitalHealth #JAMA #MachineLearning #CardioAI #MedicalImaging #DeepLearning…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 🔌 Power Heist in the Tumor: Neurons Fuel Cancer Spread 4:22
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Play Later Play Later Lists Like Liked🚨 New insights from cancer neuroscience! 🧠🧬 A groundbreaking Nature study reveals that cancer cells can steal mitochondria from nearby neurons via tunneling nanotubes — supercharging their metabolism, stemness, and metastatic potential 🌪️💥 Using a clever tool called MitoTRACER, researchers traced this “mitochondrial hijack” across cancers (breast, prostate, melanoma) and showed that recipient cells were more likely to seed distant metastases — especially in the brain 🧳🧠 🧪 Targeting this nerve–tumor energy axis may open new doors to stop metastasis in its tracks 🛑🛤️ #CancerResearch #Neuroscience #Metastasis #Mitochondria #Innovation #NaturePaper #Oncology #TumorMicroenvironment #Stemness #CellBiology #MedicalBreakthrough…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 🧠💡 Memory Matters: A Cardiologist’s Guide to Cognitive Care 5:13
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Play Later Play Later Lists Like Liked🧠💓 Cognitive decline and cardiovascular disease often go hand in hand — but they don’t have to spiral together. In our latest breakdown, we explore how cardiologists can detect, manage, and even improve cognitive impairment through smart risk factor control, lifestyle changes, and a multidisciplinary approach. From MoCA to memantine, TAVR to team-based care — it’s time to connect the mind and the heart. 📊 Evidence-based strategies 🩺 Practical tools for clinicians 💡 Insights from JACC’s state-of-the-art review 👉 Let’s build heart-smart, brain-friendly care — together. #Cardiology #CognitiveHealth #Geriatrics #HeartBrainConnection…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 Adjuvants & Alzheimer’s: A Shot at Prevention 💥🧬🧠 4:11
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Play Later Play Later Lists Like Liked🧠💉 Can vaccines protect the mind? New research suggests that AS01-adjuvanted vaccines like Shingrix and Arexvy may reduce the risk of dementia—possibly by stimulating immune pathways like IFN-γ and TLR4, not just by preventing infection. 📊 In a large US-based EHR study, those who received the RSV or shingles vaccine had a significantly lower 18-month dementia risk than flu-vaccinated peers. 🔬 The common thread? The AS01 adjuvant. 🛡️ Could this be a new frontier in neuroprotection? Let’s discuss. #Vaccines #Dementia #RSV #AS01 #Neuroimmunology #PublicHealth #Alzheimers #PrecisionMedicine…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 💉 Pump, 📉 Pressure, ⚡ Power: Inside the STEMI Shock Solution 4:26
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Play Later Play Later Lists Like LikedNew Insights from the DanGer Shock Trial! 🫀💡 Can early left ventricular unloading with a microaxial flow pump (mAFP) save lives in STEMI-related cardiogenic shock? This compelling substudy shows that mAFP not only boosts cardiac output and power, but also reduces pulmonary pressures—all while using less pharmacologic support. 📉💊 🧪 Native CO improved steadily over 48 hours, hinting at myocardial recovery. 📊 PAC data gives us a front-row seat to the physiology behind the survival curves. 🔬 The editorial dives deeper: timing, technique, and future questions. 👉 Time to rethink shock care? Dive in. #Cardiology #STEMI #CardiogenicShock #CriticalCare #mAFP #PAC #Impella #HeartFailure #DanGerShock #LVUnloading #MechanicalSupport #JACC 🩺📉🫁…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 🌐 ACHIEVE-1 Decoded: Efficacy & Safety of Orforglipron in Type 2 Diabetes 3:43
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Play Later Play Later Lists Like Liked🚨 New Breakthrough in Type 2 Diabetes Care! 💊🧬 The ACHIEVE-1 trial shows that Orforglipron, a once-daily oral, nonpeptide GLP-1 receptor agonist, delivers significant reductions in HbA1c and body weight—without injections and with minimal restrictions! 🌍📉 👨⚕️ 559 patients across 5 countries ⏱️ 40 weeks, 3 dosing arms (3, 12, 36 mg) 📊 HbA1c ↓ by up to 1.48%, weight ↓ up to 7.6% ✅ No severe hypoglycemia 📌 Mild GI side effects during dose titration This is a potential gamechanger for early T2DM care—simple, effective, and patient-friendly. 🚀 #Type2Diabetes #GLP1 #Orforglipron #Endocrinology #ClinicalTrials #PrecisionMedicine #Innovation #NEJM #ACHIEVE1 #OralTherapeutics 💥…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
🚨 Frailty matters — even in the cath lab! 🧓🫀 A new NCDR registry analysis of 1.3M+ older adults shows a clear gradient: as frailty increases, so do complications, mortality, and procedural risks during PCI. Severely frail patients faced a striking 20.3% in-hospital mortality and >50% mortality with cardiogenic shock. 🧠 It’s time to treat frailty as a vital sign — embedded in our workflow, guiding shared decisions, and shaping post-PCI care. 📊 Let’s bring team-based, geriatric-informed strategies to the forefront of interventional cardiology. #Cardiology #Frailty #PCI #PrecisionMedicine #AgingWell #GeriatricCardiology #NCDR #HealthcareInnovation #PatientCenteredCare…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 🧬 Amylin & GLP-1: Double Agents for Weight Loss & DM-CagriSema (Part II) 7:00
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Play Later Play Later Lists Like Liked🚨 Major breakthrough in obesity pharmacotherapy! The REDEFINE-1 & REDEFINE-2 trials show that once-weekly CagriSema (Cagrilintide + Semaglutide) delivers up to 20% weight loss in people with obesity—and significant glycemic improvements in those with type 2 diabetes. 💉📉 🌍 Global, double-blind RCTs ⚖️ >90% lost ≥5% body weight 🩺 SBP ↓, QoL ↑, prediabetes reversed in 88% ⚠️ GI side effects common but mostly mild 💡 CagriSema is redefining the weight loss frontier—with dual satiety and metabolic action. #Obesity #GLP1 #Cagrilintide #Semaglutide #CagriSema #WeightLoss #RCT #MetabolicHealth #Prediabetes #NovoNordisk #Endocrinology #InternalMedicine #PrecisionMedicine #Pharma #ClinicalTrials #ObesityMedicine #Amylin #GLP1Agonist #T2D #LifestyleMedicine…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 🌲 Burning Risk: How Wildfires Ignite Heart Failure 📉 4:23
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Play Later Play Later Lists Like Liked🔥 New Study Alert! 🩺 Wildfire smoke isn’t just a respiratory threat — it’s taking a toll on the heart, especially in older adults. 📊 A nationwide Medicare cohort (~22M) shows that long-term exposure to wildfire-specific PM2.5 is linked to significantly higher heart failure risk — more so than urban pollution. 📍 Vulnerable groups — women, Medicaid-eligible individuals, and low-income communities — face the highest burden. 🌫️ Tiny particles. Massive impact. 📚 Read the study: Hao et al, JACC July 2025 #Cardiology #AirPollution #WildfireSmoke #HeartFailure #EnvironmentalJustice #PM25 #PublicHealth #Epidemiology…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 🧬 Amylin & GLP-1: Double Agents for Weight Loss (Part 1) 6:10
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Play Later Play Later Lists Like Liked🧠💊 Appetite Meets Its Match: The Amylin Advantage” In this episode of Got Knowledge Doc , we explore how amylin, the lesser-known hormone co-secreted with insulin, is making a comeback — this time as part of a dual receptor strategy with GLP-1. 💡 Learn how amylin: 🧠 Activates brainstem satiety centers ⏳ Delays gastric emptying 📉 Suppresses glucagon 🔁 Synergizes with GLP-1 & leptin We break down the science behind amycretin, the first oral dual GLP-1/amylin agonist, and what it could mean for the future of obesity and metabolic care.…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 ⏱️🩸 Timing is Brain: Early DOACs in Atrial Fibrillation 4:43
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Play Later Play Later Lists Like Liked🧠💉 When should you start anticoagulation after an ischaemic stroke in atrial fibrillation? The CATALYST meta-analysis may have the answer! 📊 5,441 patients from 4 RCTs ⏱️ Early DOAC (≤4 days) reduced recurrent stroke risk at 30 days ⚖️ No increased bleeding, even in moderate stroke severity 🚫 But patients with PH2 or very severe strokes were excluded Individual Participant Data Meta-Analysis allowed detailed subgroup analysis and minimized bias 💡 Clinical Takeaway : In most mild-to-moderate strokes, don’t delay—start DOACs early! 📄 #Stroke #AtrialFibrillation #CATALYST #DOAC #Neurology #Cardiology #MetaAnalysis #IPDMA #ClinicalTrials #PrecisionMedicine #StrokePrevention…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 🧠 Restore, Regulate, Reimagine Type 1 Diabetes 3:18
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Play Later Play Later Lists Like Liked🚨 Breakthrough in Type 1 Diabetes! 🧬💉 A new study in NEJM shows that zimislecel, a fully differentiated stem cell–derived islet therapy, restored insulin production and led to insulin independence in 83% of participants! ✅ 📉 HbA1c dropped, 📈 time-in-range soared to 93%, and ⚖️ glucose variability was dramatically reduced. This marks a major step toward curing—not just managing—Type 1 diabetes. 🔬 Precision science. 💪 Real-world impact. 🌍 Hope for millions. #Type1Diabetes #StemCellTherapy #IsletTransplant #Zimislecel #NEJM #Innovation #RegenerativeMedicine #Vertex #Endocrinology #DiabetesCure…
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Dr RR Baliga's "Got Knowledge Doc" Podkast
1 🧘♂️📉 Fitness on the Floor: Predicting Death with a Sit 3:48
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Play Later Play Later Lists Like Liked🧘♂️ How Well Can You Sit and Rise from the Floor? 🪑⬆️ That simple motion might say more about your longevity than you think. A 12-year study of 4,282 adults found that lower Sit–Rise Test (SRT) scores predicted 3.8x higher natural death and 6x higher cardiovascular death rates. 😱 ✅ No equipment ✅ Under 2 minutes ✅ Predicts survival Why aren’t we using this more in routine clinical exams? 🩺 💡 If you score a 10, your 10-year survival is 97%. Score 0–4? It drops to 73%. 🔍 Let’s rethink non-aerobic fitness in preventive cardiology. #PreventiveCardiology #Longevity #FunctionalFitness #SitRiseTest #PublicHealth #CardiovascularRisk #ExerciseIsMedicine #HealthSpan #BalanceMatters #ClinicalInsights…
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